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Open AccessHighly AccessMethodology article

Semantic integration to identify overlapping functional modules in protein interaction networks

Young-Rae Cho1 email, Woochang Hwang1 email, Murali Ramanathan2 email and Aidong Zhang1 email

Department of Computer Science and Engineering, State University of New York, Buffalo, NY, USA

Department of Pharmaceutical Science, State University of New York, Buffalo, NY, USA

author email corresponding author email

BMC Bioinformatics 2007, 8:265doi:10.1186/1471-2105-8-265

Published: 24 July 2007

Additional files

Additional file 1:

Modularization results of the networks weighted by semantic similarity. Ten different output sets of modules were generated by the flow-based algorithm. The input was the protein interaction network weighted by semantic similarity. To assess the accuracy of modules, the average f-measure and the average -log(p-value) were measured for each output set.

Format: PDF Size: 61KB Download file

This file can be viewed with: Adobe Acrobat Reader

Additional file 2:

Modularization results of the networks weighted by semantic interactivity. Ten different output sets of modules were generated by the flow-based algorithm. The input was the protein interaction network weighted by semantic interactivity. To assess the accuracy of modules, the average f-measure and the average -log(p-value) were measured for each output set.

Format: PDF Size: 61KB Download file

This file can be viewed with: Adobe Acrobat Reader


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