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Open AccessHighly AccessResearch article

Missing channels in two-colour microarray experiments: Combining single-channel and two-channel data

Andy G Lynch1 email, David E Neal1 email, John D Kelly1 email, Glyn J Burtt1 email and Natalie P Thorne1,2 email

Department of Oncology, University of Cambridge, Cambridge, UK

Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge, UK

author email corresponding author email

BMC Bioinformatics 2007, 8:26doi:10.1186/1471-2105-8-26

Published: 25 January 2007

Additional files

Additional File 1:

Presented are the results of the simulation experiment. This file has six pages corresponding to 1) A key to the sheets presenting paired comparisons. 2) Paired comparisons of the methods as a whole, and stratified by the percentage of arrays that are damaged. 3) Unpaired comparisons (including reproduction of Table 2) as a whole, and stratified by the size of the differential expression effects. 4) As for page 2, but only for differential expressions that were < 0.5 in magnitude. 5) As for page 2, but only for differential expressions that were ≥ 0.5 and < 1 in magnitude. 6) As for page 2, but only for differential expressions that were ≥ 1 in magnitude.

Format: XLS Size: 112KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional File 2:

Lists of the rankings attributed to the top genes by the different methods are presented in an Excel file.

Format: XLS Size: 81KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional File 3:

Details of the approach we took to estimating the values of k.

Format: PDF Size: 95KB Download file

This file can be viewed with: Adobe Acrobat Reader


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