Table 5

Validated orphan activities

EC No.
Ranking
EC No.
Ranking
EC No.
Ranking

1.1.1.13
difficult
1.14.99.24
difficult
3.1.3.47
good
1.1.1.16
difficult
1.21.3.2
difficult
3.1.3.59
difficult
1.1.1.43
difficult
1.97.1.3
difficult
3.1.3.72
difficult
1.1.1.54
difficult
2.1.1.112
difficult
3.1.4.43
difficult
1.1.1.84
excellent
2.1.1.137
artifact
3.1.6.17
good
1.1.1.92
marginal
2.1.1.141
artifact
3.1.8.2
artifact
1.1.1.101
difficult
2.1.1.143
artifact
3.2.1.56
difficult
1.1.1.144
difficult
2.1.1.147
difficult
3.2.1.77
difficult
1.1.1.146
artifact
2.1.1.84
difficult
3.2.1.100
good
1.1.1.163
artifact
2.1.1.99
difficult
3.2.1.112
excellent
1.1.1.172
good
2.1.2.4
difficult
3.2.1.115
difficult
1.1.1.196
good
2.3.1.14
difficult
3.2.1.128
excellent
1.1.1.208
poor
2.3.1.23
difficult
3.2.1.136
difficult
1.1.1.226
excellent
2.3.1.24
artifact
3.2.1.137
poor
1.1.1.245
artifact
2.3.1.33
difficult
3.2.2.10
difficult
1.1.1.258
artifact
2.3.1.49
difficult
3.4.11.16
good
1.1.1.265
excellent
2.3.1.68
marginal
3.4.13.7
difficult
1.1.2.5
artifact
2.3.1.96
difficult
3.4.17.16
good
1.1.3.23
difficult
2.3.1.98
good
3.4.21.103
artifact
1.17.1.1
difficult
2.3.1.102
artifact
3.4.22.44
artifact
1.17.99.2
artifact
2.3.1.103
poor
3.4.22.46
artifact
1.2.1.18
artifact
2.3.1.105
poor
3.4.23.28
difficult
1.2.1.20
difficult
2.3.1.114
poor
3.4.23.30
artifact
1.2.1.23
poor
2.3.1.133
marginal
3.4.24.54
artifact
1.2.1.25
difficult
2.3.1.140
difficult
3.5.1.30
good
1.2.1.32
artifact
2.3.1.161
artifact
3.5.1.33
artifact
1.2.1.33
difficult
2.3.2.3
artifact
3.5.1.39
poor
1.2.1.52
difficult
2.3.2.7
difficult
3.5.1.58
excellent
1.2.1.54
good
2.3.3.3
difficult
3.5.1.62
artifact
1.2.1.63
marginal
2.4.1.23
poor
3.5.1.67
difficult
1.2.1.64
artifact
2.4.1.29
difficult
3.5.1.71
poor
1.2.3.6
difficult
2.4.1.41
valid
3.5.1.79
artifact
1.2.3.7
poor
2.4.1.43
difficult
3.5.2.13
poor
1.2.3.8
artifact
2.4.1.57
artifact
3.5.2.16
artifact
1.3.1.4
difficult
2.4.1.66
artifact
3.5.3.2
good
1.3.1.5
difficult
2.4.1.73
artifact
3.5.5.2
difficult
1.3.1.6
artifact
2.4.1.97
difficult
3.6.1.18
excellent
1.3.1.11
difficult
2.4.1.110
poor
3.6.1.2
artifact
1.3.1.37
difficult
2.4.1.125
difficult
3.6.1.52
artifact
1.3.7.1
difficult
2.4.1.126
valid
3.6.3.17
artifact
1.3.99.15
artifact
2.4.1.153
poor
3.6.3.24
artifact
1.3.99.21
artifact
2.4.1.167
difficult
3.6.3.28
artifact
1.4.1.11
good
2.4.1.176
difficult
3.6.4.4
artifact
1.4.1.17
good
2.4.1.180
excellent
4.1.1.24
difficult
1.4.99.4
marginal
2.4.1.184
difficult
4.1.1.52
difficult
1.4.99.5
artifact
2.4.1.215
artifact
4.1.1.56
difficult
1.5.1.21
good
2.4.2.35
difficult
4.1.1.75
difficult
1.5.99.11
artifact
2.5.1.4
difficult
4.1.2.23
difficult
1.6.5.7
artifact
2.5.1.42
difficult
4.1.2.28
difficult
1.7.3.1
difficult
2.6.1.22
difficult
4.1.2.35
difficult
1.7.3.5
valid
2.6.1.27
poor
4.1.3.35
difficult
1.8.1.5
artifact
2.6.1.32
difficult
4.2.1.5
difficult
1.10.1.1
difficult
2.6.1.33
poor
4.2.1.43
good
1.10.3.4
difficult
2.6.1.75
good
4.2.1.62
good
1.12.98.2
artifact
2.7.1.43
difficult
4.2.1.77
difficult
1.13.11.14
difficult
2.7.1.54
difficult
4.2.1.81
difficult
1.13.11.24
artifact
2.7.1.64
difficult
4.2.1.93
difficult
1.13.11.25
artifact
2.7.1.77
difficult
4.2.1.97
marginal
1.13.11.35
difficult
2.7.1.106
difficult
4.2.1.101
artifact
1.13.12.9
good
2.7.1.131
poor
4.2.2.14
artifact
1.14.11.10
difficult
2.7.1.134
difficult
4.2.3.19
artifact
1.14.11.6
poor
2.7.1.142
difficult
4.2.99.19
artifact
1.14.13.10
marginal
2.7.4.20
difficult
4.3.1.10
difficult
1.14.13.23
good
2.7.7.44
difficult
4.3.1.20
difficult
1.14.13.24
artifact
2.7.7.51
difficult
4.5.1.4
difficult
1.14.13.42
difficult
2.7.8.10
difficult
5.1.1.6
difficult
1.14.13.51
difficult
2.7.8.22
difficult
5.1.1.9
marginal
1.14.13.58
excellent
2.8.1.3
excellent
5.1.3.17
difficult
1.14.13.60
difficult
2.8.2.28
difficult
5.2.1.10
difficult
1.14.13.72
difficult
3.1.1.36
difficult
5.2.1.11
difficult
1.14.13.73
artifact
3.1.1.39
difficult
5.4.3.5
artifact
1.14.15.2
difficult
3.1.1.40
poor
5.5.1.11
good
1.14.16.5
good
3.1.1.78
artifact
5.5.1.12
artifact
1.14.99.18
artifact
3.1.2.11
difficult
5.5.1.3
difficult
1.14.99.22
artifact
3.1.3.14
difficult
6.3.1.6
difficult


3.1.3.38
poor
6.3.4.8
difficult

All 228 orphans reviewed in this study are listed. The salvageability of an orphan is ranked "difficult" when factors such as unclear species of origin, lack of molecular descriptors, or lack of comprehensive genome sequence hinder cloning of the cognate gene. Note that such rankings do not take into account the availability of molecular descriptors which enable the identification of a candidate gene in one species, and, through orthology, the identification of a candidate gene in a second species for which these descriptors are not available.

Pouliot and Karp BMC Bioinformatics 2007 8:244   doi:10.1186/1471-2105-8-244