Additional file 1.

Details of the benchmark calculation covering the 14 HLA-DR alleles. The predictive performance is shown in terms of the Pearson's correlation (upper table) and the Spearsman's rank correlation (lower table) for the SMM-align, Gibbs sampler [1], TEPITOPE [2], SVRMHC [3], MHCpred [4], and ARB methods, respectively. The SMM-PRF method refers to the extended SMM-align method including penalties for long peptides and short amino terminal peptide flanking residues, and the NetMHCII method refers to the final extended SMM align method including direct encoding of peptide flanking residues and penalties for longer peptides and short amino terminal peptide flanking residues. The first column gives the allele names as 1*0101 for DRB1*0101 etc The last column gives the number of peptide data included for each allele. For each allele, the performance of the SMM-align, Gibbs sampler, and NetMHCII methods was estimated using five-fold cross-validation as described in the text.

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Nielsen et al. BMC Bioinformatics 2007 8:238   doi:10.1186/1471-2105-8-238