Figure 4.

A subset of the E-2 complex map. After applying the E = 10^-2 threshold to the PICO interaction set, the subset of 5,352 interactions was clustered with MCL, using parameters that maximized correlation with a filtered set of GO component annotations. Interactions within clusters (4,411) were plotted with Cytoscape using the included "organic" layout algorithm. Interactions between clusters (941) were omitted for clarity. Yellow nodes indicate essential proteins; red, nonessential. For the full image please see Additional File 4.