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A high-accuracy consensus map of yeast protein complexes reveals modular nature of gene essentiality

G Traver Hart, Insuk Lee and Edward M Marcotte*

BMC Bioinformatics 2007, 8:236 doi:10.1186/1471-2105-8-236

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BioMed Central: 8 citations

Research article   Open Access

The promoter of filamentation (POF1) protein from Saccharomyces cerevisiae is an ATPase involved in the protein quality control process

Iris M Costa, Tallybia HT Nasser, Marilene Demasi, Rafaella MP Nascimento, Luis ES Netto, Sayuri Miyamoto, Fernanda M Prado, Gisele Monteiro BMC Microbiology 2011, 11:268 (28 December 2011)

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Research   Open Access

Computational approaches for detecting protein complexes from protein interaction networks: a survey

Xiaoli Li, Min Wu, Chee-Keong Kwoh, See-Kiong Ng BMC Genomics 2010, 11(Suppl 1):S3 (10 February 2010)

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Research article   Open Access

Identification of arginine- and lysine-methylation in the proteome of Saccharomyces cerevisiae and its functional implications

Chi Pang, Elisabeth Gasteiger, Marc R Wilkins BMC Genomics 2010, 11:92 (5 February 2010)

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Research article   Open Access

Exploiting gene deletion fitness effects in yeast to understand the modular architecture of protein complexes under different growth conditions

Roland A Pache, M Madan Babu, Patrick Aloy BMC Systems Biology 2009, 3:74 (18 July 2009)

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Complex fate of paralogs

Radek Szklarczyk, Martijn A Huynen, Berend Snel BMC Evolutionary Biology 2008, 8:337 (18 December 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The most common fate of duplicated genes is for their products to be found within the same protein complex, with paralogs in separate complexes being more often derived from small-scale duplications than from whole genome duplication.

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Prioritizing functional modules mediating genetic perturbations and their phenotypic effects: a global strategy

Li Wang, Fengzhu Sun, Ting Chen Genome Biology 2008, 9:R174 (16 December 2008)

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A strategy is presented to prioritize the functional modules that mediate genetic perturbations and their phenotypic effects among candidate modules.

Research article   Open Access

A simple principle concerning the robustness of protein complex activity to changes in gene expression

Jennifer I Semple, Tanya Vavouri, Ben Lehner BMC Systems Biology 2008, 2:1 (2 January 2008)

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Broad network-based predictability of Saccharomyces cerevisiae gene loss-of-function phenotypes

Kriston L McGary, Insuk Lee, Edward M Marcotte Genome Biology 2007, 8:R258 (5 December 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Loss-of-function phenotypes of yeast genes can be predicted from the loss-of-function phenotypes of their neighbours in functional gene networks. This could potentially be applied to the prediction of human disease genes.

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