Number of mouse genes represented on GenMAPP Pathways and in Gene Ontology. The unique gene content in the GenMAPP pathway archive is traced over time (blue) for the mouse genome in terms of the number of genes (left axis) and corresponding percentage of the genome (right axis). For comparison, the unique gene content annotated by Gene Ontology is shown (green). Significant gains in absolute gene content were made by collecting new pathways targeting new biology (e.g., NetPath) and by extending pathways with orthogonal datasets from coexpression and protein-protein interaction networks (latest GenMAPP count at 7095 genes, or ~25% of the genome).
Salomonis et al. BMC Bioinformatics 2007 8:217 doi:10.1186/1471-2105-8-217