Table 1 |
||||
|
Comparison of ZPS statistics for two genes: fumC, expected to be under strong purifying selection against structural variation as a housekeeping gene, and fimH, evolving under strong positive selection through SNPs as shown for genes encoding surface adhesins of pathogenic bacteria. The sample includes identical datasets of 75 strains for the two genes [9]. The p-values for the diversity measures are based on differential zonal haplotype diversity [9], while the other significance values are derived using 2 × 2 χ 2 statistic. P and E denote Primary and External zones respectively |
||||
|
zone |
fumC |
fimH |
p-values |
|
|
|
||||
|
no. of strains |
P |
69 |
27 |
< 0.0001 |
|
E |
6 |
48 |
||
|
no. of haplotypes |
P |
20 |
14 |
< 0.0001 |
|
E |
3 |
29 |
||
|
zone-wise structural hot-spot frequency (no. of hot-spots/total no. of mutations) |
P |
0.00(0/1) |
0.00(0/3) |
1.00 |
|
E |
0.00 (0/3) |
0.53 (19/36) |
0.039 |
|
|
Simpson's index (λ) |
P |
0.11 ± 0.01 |
0.12 ± 0.03 |
0.002 |
|
E |
0.39 ± 0.10 |
0.07 ± 0.01 |
||
|
α index |
P |
9.45 ± 1.80 |
11.71 ± 3.88 |
0.005 |
|
E |
2.39 ± 1.66 |
31.00 ± 8.25 |
||
|
|
||||
|
Chattopadhyay et al. BMC Bioinformatics 2007 8:187 doi:10.1186/1471-2105-8-187 |
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