Thermodynamic Distributions of (top) Significant Motifs and (bottom) Submotif-unique Significant Motifs. The distributions of Gibbs free energy values (dG) for sequences associated with effective antisense activity (green) and those associate with ineffective antisense activity (red). The difference in average dG between "good" and "bad" motifs in the subword-unique motifs (-3.45 vs. -1.66 kcal/mol) is greater than the difference in means in the entire population of significant motifs (-3.59 vs. -2.105 kcal/mol). This can be attributed to the removal of motifs from each population that contain submotifs in the opposing group.
McQuisten and Peek BMC Bioinformatics 2007 8:184 doi:10.1186/1471-2105-8-184