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Open AccessHighly AccessMethodology article

Reconstruction of human protein interolog network using evolutionary conserved network

Tao-Wei Huang1 email, Chung-Yen Lin2,3,4 email and Cheng-Yan Kao1,5 email

Department of Computer Science and Information Engineering, National Taiwan University, Taipei 106, Taiwan

Institute of Information Science, Academia Sinica, Taipei 115, Taiwan

Division of Biostatistics and Bioinformatics, National Health Research Institutes, Taipei 115, Taiwan

Institute of Fishery Science, National Taiwan University, Taipei 106, Taiwan

Institute for Information Industry, Taipei 106, Taiwan

author email corresponding author email

BMC Bioinformatics 2007, 8:152doi:10.1186/1471-2105-8-152

Published: 10 May 2007

Additional files

Additional file 1:

Data set of all predicted protein-protein interaction. A plain text with tab-delimited format. Column 1 through 12 are two protein UniProt IDs, two protein, InParanoid (IP) scores, normalized C, I, D, T, L, P, CS and p-value, respectively.

Format: TXT Size: 9.6MB Download file

Additional file 2:

Distributions of the various components of the confidence metrics and ANOVA tests between different interaction data sets. This file contains distributions of the various feature scores (D, T, L, P) and ANOVA tests between different interaction data sets, i.e. KNOWN2, TP4, TP0, BTP, PU4, PU0, BPU and RANDOMS.

Format: PDF Size: 42KB Download file

This file can be viewed with: Adobe Acrobat Reader

Additional file 3:

Top 20 total predicted putative interacting protein pairs not present in existing experimental data sets (KNOWN2). The top 20 predicted putative interacting protein pairs are listed with their OMIM ID, GO 'molecular function' and 'biological process' annotations and UniProt functional keywords.

Format: PDF Size: 78KB Download file

This file can be viewed with: Adobe Acrobat Reader


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