Additional File 1.

Determination of mutual information statistical significance. P-values are assigned to MI thresholds using a Monte Carlo simulation for different kernel widths, sample sizes (M) and for 10⁵ gene pairs so that reliable estimates are produced up to p = 10^-4 (solid lines). Extrapolation to smaller p-values is done using (dotted lines).

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Margolin et al. BMC Bioinformatics 2006 7(Suppl 1):S7   doi:10.1186/1471-2105-7-S1-S7