|
Area under the ROC curve derived from different stages of the CARAT method. |
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| Area under ROC Curve |
1X |
3X |
4X |
5X |
|
|
||||
| Stage 1 |
0.6240 |
0.5188 |
0.6575 |
0.7863 |
| Stage 2 |
0.6732 |
0.5384 |
0.6840 |
0.8128 |
| Stage 3 |
0.9319 |
0.8987 |
0.9546 |
0.9877 |
| Stage 4 |
0.9887 |
0.9759 |
0.9974 |
0.9995 |
| Stage 5 |
0.9999 |
0.9999 |
1.0000 |
1.0000 |
|
Note: 1The specificity is estimated using the 47 female samples that are a subset of the 90 normal test set samples and is restricted to the 1955 X chromosome SNPs. The sensitivity is estimated on 1955 X chromosome SNPs using DNA samples with 1X, 3X, 4X and 5X chromosomes. 2Stage 1: Single point analysis: no probe selection, no intensity adjustment on fragment length and GC content; no intensity adjustment on reference mean. 3Stage 2: Stage 1 plus probe selection. 4Stage 3: Stage 2 plus intensity adjustment on the fragment length and GC content and intensity adjustment on the reference mean. 5Stage 4: Stage 3 plus kernel smoothing with a 100 kb window. 6Stage 5: Stage 4 plus genome partitioning using the regression tree. | ||||
Huang et al. BMC Bioinformatics 2006 7:83 doi:10.1186/1471-2105-7-83 |
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