IBMT correctly estimates the proportion of false positives. All tested methods except Fox (t-test, SMT, and IBMT) correctly control for the true false positive rate. Data shown is the average of 100 simulations and the mid-strength dependence of variance on expression level with (A) dg = 4, d0 = 1, (B) dg = 4, d0 = 4, (C) dg = 4, d0 = 16, and (D) dg = 4, d0 = 100.
Sartor et al. BMC Bioinformatics 2006 7:538 doi:10.1186/1471-2105-7-538