Table 1 |
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|
Number distributions and statistical significance of 3-node subgraphs in yeast TR network |
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|
Subgraph |
|
|
|
|
|
|
|
|
||||||
|
Number in the original network |
150 845 |
2 898 |
2 655 |
392 |
307 |
118 |
|
After link randomization |
151 477 ± 152 |
3 543 ± 156 |
2 996 ± 23 |
176 ± 22 |
126 ± 148 |
2.6 ± 3.9 |
|
Significance of original (Z score) |
-4.2 |
-4.1 |
-15 |
9.7 |
1.2 |
30 |
|
Subgraph type |
Anti-motif |
Anti-motif |
Anti-motif |
Motif |
Motif |
Motif |
|
|
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|
Motifs are marked, and only subgraphs with at least 100 occurrences in the original network are listed. After link randomization the numbers of FFL, SMR and CMR subgraphs decrease, while those of DIV, CAS, and CNV subgraphs are maintained with slight increases, indicating that FFL, SMR and CMR are motifs in the TR network, while DIV, CAS and CNV are anti-motifs [8,18]. |
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|
Farkas et al. BMC Bioinformatics 2006 7:478 doi:10.1186/1471-2105-7-478 |
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