Table 1

Classification of protein kinases of S. cerevisiae*

Group or family

Group or family name

Example protein kinase

Number of protein kinases

Number of phosphorylation sites predicted


    Group I

    AGC kinases (PKA, PKG, PKC)

17

36

I_A, I_C, I_F

cAMP-dependent protein kinases

Sch9p

9

I_B

Protein kinase C (Pkc1p) family

Pkc1p

1

I_D

Ribosomal S6 kinase family

Kin82p

2

I_E

Dbf2p family

Dbf2p

2

I_G

Other AGC kinases

Yfl033cp

3

    Group II

    CaMKs

17

24

II_A

Kinases regulated by calcium/calmodulin

Cmk1p

4

II_B

5'AMP activated kinase family

Snf1p

6

II_C

Nim1p family

Hsl1p

3

II_D

Other CaMKs

Dun1p

4

    Group III

    Pro-directed (CMGC) kinases

21

23

III_A

Cyclin-dependent kinases

Cdc28p

5

III_B

Mitogen-activated kinases (MAPKs)

Slt1p

6

III_C

Glycogen synthase kinase 3β

Mds1p

4

III_D

CDK-like kinases (CLKs)

Yak1p

4

III_E

Other CMGC kinases

Sgv1p

2

    Group IV

    Ste11p/Ste20p (MAPKKKs)

10

26

IV_A

Ste11p family

Bck1p

4

IV_B

Ste20p family

Cla4p

3

IV_C

NRK Family

Cdc15p

3

    Group V

    Ste7p/NEK (MAPKKs)

8

32

V_A

Ste7p family

Ste7p

4

V_B

NIMA (NEK) family

Kin3p

1

V_C

NEK-like family

Akl1p

3

    Group VI

    Other kinases

24

96

VI_A

CK1 family

Yck1p

4

VI_B

CK2 family

Cka1p

3

VI_C

Npk1p/Hal5p family

Ptk1p

9

VI_D

Elm1p family

Pak1p **

3

VI_E

Ran1p family

Sha3p

3

VI_F

Pim1p-like family

Yal017wp

2

    Group VII

    Unique kinases

19

38

VII_A

With possible homologues

Rad53p

14

VII_B

With no known homologues

Bub1p

5


* Based on [1].

** There are two protein kinases designated Pak1p in S. cerevisiae; in this manuscript, Pak1p from group VI_D is referred to as Pak1p (Yer129wp), while Pak1p from group V_C is referred to as Prk1p (Pak1p).

Brinkworth et al. BMC Bioinformatics 2006 7:47   doi:10.1186/1471-2105-7-47

Open Data