Rapid and asymmetric divergence of duplicate genes in the human gene coexpression network

doi:10.1186/1471-2105-7-46

BMC Bioinformatics

Volume 7

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Research article

Rapid and asymmetric divergence of duplicate genes in the human gene coexpression network

Wen-Yu Chung¹^,6 , Reka Albert² , Istvan Albert⁵ , Anton Nekrutenko³^,5^,6 and Kateryna D Makova⁴^,6

¹Department of Computer Science and Engineering, Penn State University, University Park, PA, 16802, USA

²Department of Physics, Penn State University, University Park, PA, 16802, USA

³Department of Biochemistry and Molecular Biology, Penn State University, University Park, PA, 16802, USA

⁴Department of Biology, Penn State University, University Park, PA, 16802, USA

⁵Department of Huck Institute for Life Sciences, Penn State University, University Park, PA, 16802, USA

⁶Department of Center for Comparative Genomics and Bioinformatics, Penn State University, University Park, PA, 16802, USA

author email corresponding author email

BMC Bioinformatics 2006, 7:46doi:10.1186/1471-2105-7-46


Published:	27 January 2006

Additional files

Additional File 1:

The numerical description of the networks

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Additional File 2:

Degree distributions of networks generated from a combination of thresholds: T (tissue) and R (Pearson correlation coefficient). The degree distribution for the network with T ≥ 7 and R ≥ 0.7 is shown in Figure 1

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Additional File 3:

The scatter plots between clustering coefficient c and node degree k for (A) all genes, (B) ubiquitously expressed genes, and (C) nonubiquitously expressed genes.

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Additional File 4:

The degree distribution of the studied network (T ≥ 7 and R ≥ 0.7) for (A) duplicate genes and (B) singletons.

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Additional File 5:

Scripts for the study

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Additional File 6:

Network binary matrix.

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Additional File 7:

The set of independent duplicate gene pairs.

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