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Attributes used for predicting functional effects of missense mutations |
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| Abbreviation |
Type |
Description |
Information |
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| effect |
Discrete |
Effect of mutation on functionality |
Class |
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| ac |
Continuous |
Solvent accessible area of native AA |
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| rac |
Continuous |
Accessibility relative to maximum accessibility in training set |
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| bf |
Continuous |
Normalised B-factor of native AA |
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| nbf |
Continuous |
Normalised B-factor of structural neighbourhood of native AA |
Structural |
| bur |
Discrete |
Mutant AA is charged AA at buried site |
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| trn |
Discrete |
Mutant AA occurs at glycine or proline in a turn |
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| hlx |
Discrete |
Mutant AA occurs in helical region and involves glycine or proline |
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| ifc |
Discrete |
Native AA is near subunit interface |
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| nrent |
Continuous |
Phylogenetic entropy of structural neighbourhood of native AA |
Structural + Evolutionary |
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| rent |
Continuous |
Normalised phylogenetic entropy of native AA |
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| cnsd |
Discrete |
Native AA is at conserved position in phylogenetic profile |
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| ncnsd |
Discrete |
Native AA is near conserved position in phylogenetic profile |
Evolutionary |
| uslaa |
Discrete |
Mutant AA is not in phylogenetic profile |
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| uslby |
Discrete |
Mutant AA is not in the smallest AA class that includes the phylogenetic profile |
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Needham et al. BMC Bioinformatics 2006 7:405 doi:10.1186/1471-2105-7-405 |
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