Curation of complex, context-dependent immunological data

doi:10.1186/1471-2105-7-341

BMC Bioinformatics

Volume 7

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Vita R
Vaughan K
Zarebski L
Salimi N
Fleri W
Grey H
Sathiamurthy M
Mokili J
Bui HH
Bourne PE
Ponomarenko J
de Castro R
Chan RK
Sidney J
Wilson SS
Stewart S
Way S
Peters B
Sette A

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Vita R
Vaughan K
Zarebski L
Salimi N
Fleri W
Grey H
Sathiamurthy M
Mokili J
Bui HH
Bourne PE
Ponomarenko J
de Castro R
Chan RK
Sidney J
Wilson SS
Stewart S
Way S
Peters B
Sette A
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Curation of complex, context-dependent immunological data

Randi Vita¹ , Kerrie Vaughan¹ , Laura Zarebski¹ , Nima Salimi¹ , Ward Fleri¹ , Howard Grey¹ , Muthu Sathiamurthy¹ , John Mokili¹ , Huynh-Hoa Bui¹ , Philip E Bourne²^,3 , Julia Ponomarenko² , Romulo de Castro Jr¹ , Russell K Chan¹ , John Sidney¹ , Stephen S Wilson¹ , Scott Stewart⁴ , Scott Way⁴ , Bjoern Peters¹ and Alessandro Sette¹

¹La Jolla Institute for Allergy and Immunology, 3030 Bunker Hill Street, Suite 326, San Diego, California, USA

²San Diego Supercomputer Center, P.O. Box 85608, San Diego, California, USA

³Department of Pharmacology, University of California, San Diego, 9500 Gilman Drive La Jolla California, USA

⁴Science Applications International Corporation, 10260 Campus Point Drive, MS-A2F, San Diego, California, USA

author email corresponding author email

BMC Bioinformatics 2006, 7:341doi:10.1186/1471-2105-7-341


Published:	12 July 2006

Abstract

Background

The Immune Epitope Database and Analysis Resource (IEDB) is dedicated to capturing, housing and analyzing complex immune epitope related data http://www.immuneepitope.org webcite.

Description

To identify and extract relevant data from the scientific literature in an efficient and accurate manner, novel processes were developed for manual and semi-automated annotation.

Conclusion

Formalized curation strategies enable the processing of a large volume of context-dependent data, which are now available to the scientific community in an accessible and transparent format. The experiences described herein are applicable to other databases housing complex biological data and requiring a high level of curation expertise.