Dynamic simulations. Dynamic simulations of the example shown in Figure 3b using the parameter values presented in Table 5. Here we compare the levels of occupancy of the three protein domains. The left picture shows the level of occupancy of domain 1, the second picture shows the levels of occupancy of domain 2 and the right picture shows that of domain 3. The results show that the reduced model we obtained by applying our method (model 3) accurately describes the real time course represented by a complete mechanistic model (model 1). The other model which follows from a number of reasonable simplifications which can also be found in literature provides completely different results.
Conzelmann et al. BMC Bioinformatics 2006 7:34 doi:10.1186/1471-2105-7-34