Interaction motifs. Generic examples of scaffold proteins with 3 or 4 docking sites. (a) A scaffold protein with 3 distinct docking sites which do not interact. (b) Another pattern of domain interactions for the same scaffold protein. Here binding domain 1 controls the other two domains. (c) A scaffold protein with 4 docking sites and a more complex pattern of domain interactions. Each pattern of domain interactions can be translated into special kinetic properties (like exemplified in Figure 2).
Conzelmann et al. BMC Bioinformatics 2006 7:34 doi:10.1186/1471-2105-7-34