Table 1

Specificity of designed sequences.

Potential

Average Z-score ratio

SDev Z-score ratio

Ranking (median)

Target fold in top 1% (A)

Target fold in top 10%

Average seq. identity

Correlation between (A) and mean entropy/site

μ

-0.12

0.18

2249

0.5%

4.8%

5.76 %

-0.26

μ + α_14ac

-0.10

0.18

2090

0.4%

6.3%

6.65 %

-0.04

μ + ε

0.13

0.16

816.8

10.7%

33.5%

6.69 %

0.23

μ + α_14ac + ε

0.45

0.23

32.7

53.6%

77.5%

7.82 %

0.64

Scores of a fold recognition experiment for designed sequences (see Methods). 1,200 sequences were sampled from p(s | c, θ) for each potential, and submitted to THREADER for fold recognition. Z-score ratio: Z-score of designed sequence/Z-score of native sequence in target fold.

Kleinman et al. BMC Bioinformatics 2006 7:326   doi:10.1186/1471-2105-7-326