Figure 5.

Predicted complete protein complexes for L. lactis and P. aeruginosa, based on a pairwise comparison with protein complexes found in metabolic networks of L. plantarum, B. subtilis and E. coli. A higher fraction of protein complexes is completely conserved between L. plantarum, B. subtilis and L. lactis, compared to E. coli and L. lactis. As L. plantarum, B. subtilis and L. lactis are all gram-positives and E. coli is a proteobacterium, the phylogenetic relationship between species appears of influence in number of completely conserved protein complexes. This is further supported by applying the AUTOGRAPH-method to the annotated genome of P. aeruginosa, which shows that the fraction of (predicted) complete protein complexes is relatively higher between P. aeruginosa and E. coli (i.e. both are proteobacteria), compared to P. aeruginosa and the gram-positive bacteria (L. plantarum and B. subtilis).