Table 4 |
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|
Manual curation of Gene Cluster #18 genes |
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|
Protein description |
Gene Sym Symbol |
LocusLink ID |
Function |
Reference |
|
|
|
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|
A |
CD72 |
Cd72 |
12517 |
BCR coreceptor |
32–34 35 |
|
dual specificity phosphatase 14 |
Dusp14 |
56405 |
lymphocyte signaling |
36 |
|
|
mitogen activated protein kinase kinase kinase kinase 1 |
Map4k1 |
26411 |
lymphocyte signaling |
37–39 |
|
|
mitogen activated protein kinase kinase 3 |
Map2k3 |
26397 |
lymphocyte signaling |
40, 41 |
|
|
serine/threonine kinase receptor associated protein |
Strap |
20901 |
TGFbeta signaling |
42 |
|
|
dishevelled associated activator of morphogenesis 1 |
Daam1 |
208846 |
Wnt signaling |
43 |
|
|
FK506 binding protein 1a |
Fkbp1a |
14225 |
BCR signaling/apoptosis |
44–46 |
|
|
nuclear factor of activated T-cells, cytoplasmic 2 interacting protein |
Nfatc2ip |
18020 |
BCR signaling/apoptosis |
44–46 |
|
|
sorting nexin 5 |
Snx5 |
69178 |
endocytosis |
47, 48 |
|
|
IQ motif containing GTPase activating protein 1 |
Iqgap1 |
29875 |
vesicle formation |
49, 50 |
|
|
amyotrophic lateral sclerosis 2 (juvenile) homolog (human) |
Als2 |
74018 |
endosome fusion/Rab GEF |
51, 52 |
|
|
RAB18, RAS family |
Rab18 |
19330 |
endocytosis/vesicle recycling |
53–56 56 |
|
|
RAB22, RAS family |
Rab22a |
19334 |
early endosome trafficking |
56, 57 |
|
|
Proton pump, subunit V0B (21 kDa) |
Atp6v0b |
114143 |
vesicle acidification |
58–60 |
|
|
Proton pump, subunit V1G1 (13 kDa) |
Atp6v1g1 |
66290 |
vesicle acidification |
58–60 |
|
|
Proton pump, subunit V1C1 (42 kDa) |
Atp6v1c1 |
66335 |
vesicle acidification |
58–60 |
|
|
similar to Proton pump, subunit V1F |
76610 |
vesicle acidification |
58–60 |
||
|
Proton pump accessory protein 2 |
Atp6ap2 |
70495 |
vesicle acidification |
61, 62 |
|
|
Chloride channel 7 |
Clcn7 |
26373 |
vesicle pH regulation |
63, 64 |
|
|
dystrobrevin binding protein 1 (dysbindin) |
Dtnbp1 |
94245 |
lysosome formation |
65 |
|
|
cystatin B |
Cstb |
13014 |
cathepsin protease inhibitor |
66–68 |
|
|
hexosaminidase A |
Hexa |
15211 |
hydrolase |
69–71 |
|
|
ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease) |
Cln3 |
12752 |
lysosome function |
72 |
|
|
HSP70 binding protein |
Hspbp1 |
66245 |
Ag processing/loading |
73 |
|
|
similar to HSPC135 |
66067 |
chaperone (?), GTPase (?) |
|||
|
HSPC245 homolog |
chaperone (?) |
||||
|
N-ethylmaleimide sensitive fusion protein attachment protein alpha |
Napa |
108124 |
vesicle fusion |
74, 75 |
|
|
RAB9, RAS family |
Rab9 |
56382 |
vesicle tethering |
76, 77 |
|
|
activating transcription factor 1 |
Atf1 |
11908 |
MHC expression |
78 |
|
|
Sec61 alpha |
Sec61a1 |
53421 |
ER translocation |
79 |
|
|
signal sequence receptor, alpha |
Ssr1 |
107513 |
MHCII chaperone |
80 |
|
|
calmegin |
Clgn |
12745 |
MHC chaperone |
81, 82 |
|
|
similar to signal peptidase SPC22/23 |
76687 |
secretory protein processing |
83 |
||
|
vacuolar protein sorting 29 |
Vps29 |
56433 |
retrograde vesicle transport |
84, 85 |
|
|
reticulon 3 |
Rtn3 |
20168 |
exocytosis |
86, 87 |
|
|
tubulin, alpha 6 |
Tuba6 |
22146 |
cytoskeletal trafficking |
88, 89 |
|
|
CD63 |
Cd63 |
12512 |
MHCII coreceptor |
90–92 |
|
|
source of immunodominant MHC-associated peptides |
Simp |
68292 |
MHC peptide |
93 |
|
|
B |
24-dehydrocholesterol reductase |
Dhcr24 |
74754 |
Cholesterol biosynthesis |
94 |
|
fatty acid binding protein 5, epidermal |
Fabp5 |
16592 |
Fatty acid intracellular transport |
95 |
|
|
phosphatidylethanolamine binding protein |
Pbp |
23980 |
Membrane lipid transport |
96 |
|
|
prostaglandin D2 synthase 2, hematopoietic |
Ptgds2 |
54486 |
|||
|
peroxisome biogenesis factor 1 |
Pex1 |
71382 |
Peroxisomal protein tranport |
97 |
|
|
C |
beclin 1 (coiled-coil, myosin-like BCL2-interacting protein) |
Becn1 |
56208 |
Tumor suppression |
98, 99 |
|
caspase 4, apoptosis-related cysteine protease |
Casp4 |
12363 |
Apoptosis |
100–102 |
|
|
Cd27 binding protein (Hindu God of destruction) |
Siva |
30954 |
Apoptosis |
103, 104 |
|
|
D |
polymyositis/scleroderma autoantigen 2 |
Pmscl2 |
50912 |
RNA processing autoantigen |
105 |
|
Sjogren's syndrome/scleroderma autoantigen 1 homolog (human) |
Sssca1 |
56390 |
centromeric autoantigen |
106 |
|
|
amyotrophic lateral sclerosis 2 (juvenile) homolog (human) |
Als2 |
74018 |
endosome fusion/Rab GEF |
51, 52 |
|
|
|
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|
Genes found in Gene Cluster #18 with functions related to (A) intracellular trafficking, BCR signaling, vesicle processing and function, and antigen processing and presentation, (C) apoptosis, and (D) B cell-related autoimmune disease. (B) Genes annotated with "transporter" activity whose roles are not yet known to be associated with intracellular trafficking. |
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|
Lee et al. BMC Bioinformatics 2006 7:237 doi:10.1186/1471-2105-7-237 |
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