Table 3

Top scoring SMID-BLAST ligand hits for TrpRS and TyrRS across a wide range of organisms. 82 TrpRS sequences and 83 TyrRS sequences were employed. The expected best ligand is shown in bold.

Ligand to TrpRS

Hits

Ligand to TyrRS

Hits


Top scoring ligand, ignoring ATP and Mg++

Tryptophanyl Adenylate

80

Tyrosinal Adenylate

37

Tyrosinal

2

SB-239629

18

Tryptophanyl Adenylate

13

SB-243545

9

SB-284485

5

D-tyrosine

1

Top scoring ligand, ignoring ATP, Mg++ and binding site occupancy

Tryptophanyl Adenylate

36

SB-239629

50

L-tryptophan

22

D-tyrosine

31

D-tyrosine

10

Tyrosinal Adenylate

1

SB-239629

7

Tyrosinal

1

Tyrosinal

6

L-tryptophanamide

1


Snyder et al. BMC Bioinformatics 2006 7:152   doi:10.1186/1471-2105-7-152

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