Table 3 |
||||
|
Top scoring SMID-BLAST ligand hits for TrpRS and TyrRS across a wide range of organisms. 82 TrpRS sequences and 83 TyrRS sequences were employed. The expected best ligand is shown in bold. |
||||
|
Ligand to TrpRS |
Hits |
Ligand to TyrRS |
Hits |
|
|
|
||||
|
Top scoring ligand, ignoring ATP and Mg++ |
Tryptophanyl Adenylate |
80 |
Tyrosinal Adenylate |
37 |
|
Tyrosinal |
2 |
SB-239629 |
18 |
|
|
Tryptophanyl Adenylate |
13 |
|||
|
SB-243545 |
9 |
|||
|
SB-284485 |
5 |
|||
|
D-tyrosine |
1 |
|||
|
Top scoring ligand, ignoring ATP, Mg++ and binding site occupancy |
Tryptophanyl Adenylate |
36 |
SB-239629 |
50 |
|
L-tryptophan |
22 |
D-tyrosine |
31 |
|
|
D-tyrosine |
10 |
Tyrosinal Adenylate |
1 |
|
|
SB-239629 |
7 |
Tyrosinal |
1 |
|
|
Tyrosinal |
6 |
|||
|
L-tryptophanamide |
1 |
|||
|
|
||||
|
Snyder et al. BMC Bioinformatics 2006 7:152 doi:10.1186/1471-2105-7-152 |
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