An overview of how protein-small molecule interactions are identified from the PDB and utilized to generate SMID records. The process of 'Interaction Tagging' involves the identification of protein-small molecule interactions that involve i) single atom contacts ii) an unknown protein sequence iii) a biologically irrelevant small molecule iv) false contacts with biologically relevant ions using a Support Vector Machine. See text for details.
Snyder et al. BMC Bioinformatics 2006 7:152 doi:10.1186/1471-2105-7-152