Table 1

Extracted sub-graphs. EcoCyc-ids of the reactions, their corresponding enzyme annotations, their observed regulation due to a changing from aerobic to anaerobic conditions and the confidence value for this observation. Listed are the first 10 extracted sub-graphs.

id
enzymes
regulation
p-value

1st extracted sub-graph (formate metabolism)
FHLMULTI-RXN
formate hydrogenlyase complex
1
3.8e-16
FORMYLTHFDEFORMYL-RXN
formyltetrahydrofolate deformylase
-1
0.0015
GTP-CYCLOHYDRO-I-RXN
GTP cyclohydrolase I
-1
0.00088
GTP-CYCLOHYDRO-II-RXN
GTP cyclohydrolase II
(1)
0.57
H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN
dihydroneopterin triphosphate pyrophosphohydrolase
(0)
1
H2NTPEPIM-RXN
dihydroneopterin triphosphate 2'-epimerase
-1
1.024e-05
KETOBUTFORMLY-RXN
2-ketobutyrate formate-lyase
(-1)
0.20
PYRUVFORMLY-RXN
pyruvate formate-lyase
1
2.2e-18
RXN0-1382
formyl-CoA transferase
-1
0.023
TRANS-RXN-1
transporter
1
4.5e-20
2nd extracted sub-graph (formate metabolism)
FHLMULTI-RXN
formate hydrogenlyase complex
1
3.8e-16
FORMYLTHFDEFORMYL-RXN
formyltetrahydrofolate deformylase
-1
0.0015
GTP-CYCLOHYDRO-I-RXN
GTP cyclohydrolase I
-1
0.00088
GTP-CYCLOHYDRO-II-RXN
GTP cyclohydrolase II
(1)
0.57
KETOBUTFORMLY-RXN
2-ketobutyrate formate-lyase
(-1)
0.20
PYRUVFORMLY-RXN
pyruvate formate-lyase
1
2.2e-18
RXN0-443

(0)
1
TRANS-RXN-1
transporter
1
4.5e-20
3rd extracted sub-graph (leucine)
ABC-35-RXN
Transporters
-1
4.1e-09
BRANCHED-CHAINAMINOTRANSFERLEU-RXN
branched chain amino acid aminotransferase
1
0.080
LEUCINE – TRNA-LIGASE-RXN
leucyl-tRNA synthetase
(1)
0.13
LEUCYLTRANSFERASE-RXN
leucyl phenylalanyl-tRNA-protein transferase
1
0.011
RXN0-261

(0)
1
TRANS-RXN-126B
transporter
1
6.2e-10
4th extracted sub-graph (aspartate metabolism)
2-METHYLCITRATE-SYNTHASE-RXN
methylcitrate synthase
(1)
0.32
ARGSUCCINSYN-RXN
argininosuccinate synthase
1
0.027
ASNSYNA-RXN
aspartate-ammonia ligase
1
0.0032
ASPARTASE-RXN
aspartate ammonia-lyase
1
1.6e-06
ASPARTATE – TRNA-LIGASE-RXN
aspartyl-tRNA synthetase
(1)
0.61
ASPARTATEKIN-RXN
aspartate kinase I
1
0.0082
ASPCARBTRANS-RXN
aspartate carbamoyltransferase
(-1)
0.16
ASPDECARBOX-RXN
aspartate-1-decarboxylase
(1)
0.23
L-ASPARTATE-OXID-RXN
L-aspartate oxidase
1
0.00033
PEPCARBOXYKIN-RXN
phosphoenolpyruvate carboxykinase (ATP)
(1)
0.58
PEROXID-RXN
thiol peroxidase
(1)
0.20
PYRIDOXKIN-RXN
pyridoxal kinase 2
(-1)
0.045
PYROXALTRANSAM-RXN
pyridoxamine-oxaloacetate transaminase
(0)
1
QUINOLINATE-SYNTHE-MULTI-RXN
quinolinate synthetase
1
0.00051
RXN0-267
thiol peroxidase 2
-1
8.1e-08
SAICARSYN-RXN
phosphoribosylaminoimidazole- succinocarboxamide synthase
1
9.0e-07
TRANS-RXN-106A
transporter
1
0.015
TRANS-RXN-122A
transporter
1
2.2e-06
5th extracted sub-graph (formate metabolism)
FHLMULTI-RXN
formate hydrogenlyase complex
1
3.8e-16
FORMYLTHFDEFORMYL-RXN
formyltetrahydrofolate deformylase
-1
0.0015
GTP-CYCLOHYDRO-I-RXN
GTP cyclohydrolase I
-1
0.00088
GTP-CYCLOHYDRO-II-RXN
GTP cyclohydrolase II
(1)
0.57
H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN
dihydroneopterin triphosphate pyrophosphohydrolase
(0)
1
H2NTPEPIM-RXN
dihydroneopterin triphosphate 2'-epimerase
-1
1.0e-05
KETOBUTFORMLY-RXN
2-ketobutyrate formate-lyase
(-1)
0.2
PYRUVFORMLY-RXN
pyruvate formate-lyase
1
2.2e-18
RXN0-443

(0)
1
TRANS-RXN-1
transporter
1
4.5e-20
6th extracted sub-graph (formate metabolism)
3.5.1.88-RXN
dihydroxyacetone kinase
-1
0.059
FORMYLTHFDEFORMYL-RXN
formyltetrahydrofolate deformylase
-1
0.0015
GARTRANSFORMYL2-RXN
GAR transformylase 2
(-1)
0.41
GTP-CYCLOHYDRO-I-RXN
GTP cyclohydrolase I
-1
0.00088
METHENYLTHFCYCLOHYDRO-RXN
methenyltetrahydrofolate cyclohydrolase
1
0.0052
PYRUVFORMLY-RXN
pyruvate formate-lyase
1
2.2e-18
RXN0-1382
formyl-CoA transferase
-1
0.023
RXN0-443

(0)
1
TRANS-RXN-1
transporter
1
4.5e-20
7th extracted sub-graph (lysine)
DIAMINOPIMDECARB-RXN
diaminopimelate decarboxylase
-1
0.0012
GLU6PDEHYDROG-RXN
glucose 6-phosphate-1-dehydrogenase
1
0.027
LYSDECARBOX-RXN
lysine decarboxylase 2
(-1)
0.14
LYSINE – TRNA-LIGASE-RXN
lysyl tRNA synthetase
-1
0.0060
RXN0-1961
tRNA-Ile-lysidine synthetase
-1
0.015
RXN0-963
fructoselysine 6-phosphate deglycase
1
0.0059
TRANS-RXN-58
Transporter
-1
0.049
TRANS-RXN-68
Transporter
(0)
0.81
8th extracted sub-graph (Glycolysis)
6-PHOSPHO-BETA-GLUCOSIDASE-RXN
phenylacetate-CoA ligase
1
2.9e-06
AMYLOMALT-RXN
amylomaltase
(-1)
0.34
GALACTURIDYLYLTRANS-RXN
UDP-glucose-hexose-1-phosphate uridylyltransferase
-1
1.1e-06
GLUCDEHYDROG-RXN
glucose dehydrogenase (pyrroloquinoline-quinone)
-1
5.3e-05
GLUCOKIN-RXN
glucokinase
1
1.4e-07
GLUCOSE-1-PHOSPHAT-RXN
glucose-1-phosphatase
(0)
0.78
MALTACETYLTRAN-RXN
maltose acetyltransferase
(-1)
0.43
MALTDEG-RXN
maltose degrading enzyme
(-1)
0.34
MALTODEG-RXN
maltose degrading enzyme 2
(-1)
0.34
MALTODEXGLUCOSID-RXN
maltodextrin glucosidase
(1)
0.26
PGLUCISOM-RXN
phosphoglucose isomerase
1
3.3e-07
RXN0-2543
flavorubredoxin reductase
(-1)
0.13
TRE6PHYDRO-RXN
trehalose-6-phosphate hydrolase
(-1)
0.097
TREHALOSE6PSYN-RXN
trehalose-6-phosphate synthase
(0)
0.87
9th extracted sub-graph (Glycolysis/NAD biosynthesis)
QUINOLINATE-SYNTHA-RXN
quinolinate synthetase A
1
0.0016
QUINOLINATE-SYNTHE-MULTI-RXN
quinolinate synthetase
1
0.00051
RHAMNULPALDOL-RXN
rhamnulose-1-phosphate aldolase
(-1)
0.25
RXN0-313
fructose 6-phosphate aldolase 1
(-1)
0.51
TAGAALDOL-RXN
tagatose-16-bisphosphate aldolase 1
(1)
0.60
TRIOSEPISOMERIZATION-RXN
triose phosphate isomerase
1
1.9e-12
10th extracted sub-graph (aspartate metabolism)
2-METHYLCITRATE-SYNTHASE-RXN
methylcitrate synthase
(1)
0.32
ARGSUCCINSYN-RXN
argininosuccinate synthase
1
0.027
ASNSYNA-RXN
aspartate-ammonia ligase
1
0.0032
ASPARTASE-RXN
aspartate ammonia-lyase
1
1.6e-06
ASPARTATE – TRNA-LIGASE-RXN
aspartyl-tRNA synthetase
(1)
0.61
ASPARTATEKIN-RXN
aspartate kinase I
1
0.0082
ASPCARBTRANS-RXN
aspartate carbamoyltransferase
(-1)
0.16
ASPDECARBOX-RXN
aspartate-1-decarboxylase
(1)
0.23
L-ASPARTATE-OXID-RXN
L-aspartate oxidase
1
0.00033
PEPCARBOXYKIN-RXN
phosphoenolpyruvate carboxykinase (ATP)
(1)
0.57
PEROXID-RXN
thiol peroxidase
(1)
0.20
PYRIDOXKIN-RXN
pyridoxal kinase 2
-1
0.045
PYROXALTRANSAM-RXN
pyridoxamine-oxaloacetate transaminase
(0)
1
QUINOLINATE-SYNTHE-MULTI-RXN
quinolinate synthetase
1
0.00051
RXN0-267
thiol peroxidase 2
-1
8.1e-08
SAICARSYN-RXN
phosphoribosylaminoimidazole- succinocarboxamide synthase
1
9.0e-07
TRANS-RXN-122A
transporter
1
2.2e-06

König et al. BMC Bioinformatics 2006 7:119   doi:10.1186/1471-2105-7-119