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Metabolite coupling in genome-scale metabolic networks

Scott A Becker, Nathan D Price and Bernhard Ø Palsson*

BMC Bioinformatics 2006, 7:111 doi:10.1186/1471-2105-7-111

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Research article   Open Access

Three factors underlying incorrect in silico predictions of essential metabolic genes

Scott A Becker, Bernhard O Palsson BMC Systems Biology 2008, 2:14 (4 February 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

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A network perspective on the evolution of metabolism by gene duplication

Juan Díaz-Mejía, Ernesto Pérez-Rueda, Lorenzo Segovia Genome Biology 2007, 8:R26 (27 February 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

In silico models trying to explain the origin and evolution of metabolism are improved with the inclusion of specific functional constraints, such as the preferential coupling of reactions.

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