 Oral presentationPrioritisation of Disease Gene Candidates: A Systems Biology ApproachFrances S Turner  Medical Research Council Human Genetics Unit, Western General Hospital, Edinburgh University, UK  author email corresponding author email
from BioSysBio: Bioinformatics and Systems Biology Conference
Edinburgh, UK. 14–15 July 2005 BMC Bioinformatics 2005,
6(Suppl 3):S14doi:10.1186/1471-2105-6-S3-S14
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21 September 2005 |
First paragraph (this article has no abstract)
Although much work has been done in the linkage mapping of many common, genetically complex diseases studies have typically identified disease susceptibility regions of tens of megabases, rather than individual genes [1]. Typically genes are prioritized for further study, by looking for those whose characteristics (function/expression etc) fit with what is already known about the disease. However, by definition such approaches would fail to identify novel disease genes that do not fit with prior knowledge of the disease or where little is known about the underlying aetiology of the disease. | 
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