Figure 14.

The locations of H-369 (yellow) and deoxyuridines (green) within the NS3h crystal structure are in close proximity. H-369 is located within domain 2, and protrudes into the channel where the oligonucleotide binds near the 5' end. A peptide (364–372: HLIFCHSK) (red) was identified by CLPM as the site of photocrosslinking.