Table 5

Summary of results from the EAE example. Numbers of genes declared significantly differentially expressed by different numbers of experiments and the fixed and random effects meta-analyses in the observed data example. The False Discovery Rate (FDR) for the meta-analyses and each experiment separately was controlled at 0.05. There were 65 Integration-Driven Discoveries (IDD's) and 5518 Integration-Driven Revisions (IDR's). There were 32 IDR's that had been declared significantly differentially expressed by all seven experiments.

Fixed Effects Model

Random Effects Model

Number of Experiments Declaring

Number of Genes Declared

Number of Genes Declared

Significance

Not Significant

Significant

Not Significant

Significant

0

1792

301

2028

65

1

804

2265

1558

1511

2

749

1409

1869

289

3

625

1512

1662

475

4

328

1319

1084

563

5

152

908

617

443

6

54

464

254

264

7

8

85

32

61

4512

8263

9104

3671

Stevens and Doerge BMC Bioinformatics 2005 6:57   doi:10.1186/1471-2105-6-57