Figure 1.

Summary of real and simulated RN_U34 Affymetrix chip data. (a) The real mismatch (MM) intensities are from a RN_U34 Affymetrix chip, and their histogram closely resembles a Gamma distribution with a long tail. (b) The simulated MM intensities are drawn from a Gamma distribution to resemble the real MM intensities. (c) The relationship between the SLR from a simulated lab and the standard error of the SLR for each gene on the RN_U34 Affymetrix chip. Large absolute SLR's with small standard errors indicate significant differential expression. (d) A comparison of SLR estimates from two simulated labs shows general agreement, with some differences between labs.