Receiver Operator Curves generated by the AffyComp suite for the SpikeIn133 dataset at 2-fold changes. A. The MAS5 algorithm shows noticeable improvement when Harshlight is used to excise blemishes, both for missing value substitutions as well as for median substitution: approximately 2 extra true positives per chip are discovered. B. The GCRMA algorithm shows a slight improvement of about 0.5 extra true positives per chip under median substitution.
Suárez-Fariñas et al. BMC Bioinformatics 2005 6:294 doi:10.1186/1471-2105-6-294