Figure 1.

A scheme illustrates the procedure of inferring DDIs from PPIs. Colored shapes represent sequence signatures. Suppose protein H (the host) interacts with four guest proteins (G1, G2, G3, G4) and all signatures in the schema are known with the exception of the one represented by purple hexagon. In this case only interactions with G1 and G2 are useful in inferring DDIs. In this study we used MEME program to identify all signatures shared by guests.