Table 1

Benchmark comparison of ASPIC with other similar tools


ASPIC
ASAP
ASD
ACEVIEW





GENE
#introns (#novel)
#TS
#EST/splice
#introns (#ASPIC)
#TS
#introns (#ASPIC)
#TS
#introns (#ASPIC)
#TS

ABCB10
12(0)
2
12.42
12(12)
1
Not Found

13(12)
3
ACADM
21(1)
15
31.52
15(14)
6
Not Found

22(20)
14
ACTN2
23(0)
28
19.09
20(20)
1
22(22)
4
23(23)
8
ADAM15
41(4)
67
40.07
13(13)
4
29(29)
11
56(37)
25
ADAMTS4
8(0)
3
8.63
7(7)
1
8(8)
4
8(8)
3
ADORA1
13(1)
10
4.69
8(8)
4
12(12)
9
10(9)
7
ADORA3
15(13)
5
6.13
2(2)
2
Not Found

3(2)
3
AGL
40(1)
12
14.48
38(38)
1
Not Found

39(39)
10
AGRN
41(4)
21
16.98
35(32)
1
Not Found

45(37)
11
AGT
7(2)
17
52.86
4(3)
1
Not Found

9(5)
8
AHCYL1
26(4)
35
48.50
19(19)
5
19(19)
4
26(22)
13
AKR7A2
9(1)
6
73.33
6(6)
1
7(7)
2
31(8)
15
ALDH9A1
17(4)
10
39.29
11(11)
2
Not Found

16(13)
7
ALPL
15(0)
8
19.47
14(13)
3
13(13)
3
17(15)
9
AMPD1
14(0)
4
7.64
13(13)
1
Not Found

45(14)
12
ANGPTL1
6(0)
3
10.50
5(5)
1
Not Found

6(6)
4
ANGPTL3
6(0)
5
19.17
6(6)
2
Not Found

8(6)
7
ANXA9
15(1)
3
14.40
13(13)
1
14(13)
2
16(14)
6
AP4B1
18(0)
22
14.61
12(12)
1
17(16)
12
16(16)
14
APCS
2(1)
5
62.50
1(1)
1
Not Found

1(1)
1
ARHGEF2
32(1)
37
15.19
22(22)
3
26(25)
6
35(31)
17
ARHGEF11
47(1)
9
7.70
42(42)
2
41(40)
6
46(45)
17
ARHGEF16
14(2)
12
18.64
10(10)
1
Not Found

15(12)
5
ARNT
26(1)
14
11.73
20(18)
1
22(21)
3
38(26)
14
ARPC5
4(1)
2
120.75
3(3)
1
4(2)
2
6(3)
4
ARTN
8(0)
10
5.25
7(7)
4
6(6)
3
7(7)
10
ATAD3A
22(2)
10
36.41
16(16)
2
Not Found

58(21)
27
ATP1B1
11(2)
12
59.27
7(7)
1
10(9)
4
11(8)
10
ATP2B4
29(3)
11
8.07
22(22)
5
23(23)
3
26(26)
14
Clorf10
2(0)
1
7.00
2(2)
1
Not Found

2(2)
2
Clorf26
22(0)
7
7.91
17(17)
1
Not Found

23(22)
6
C1QB
3(1)
3
25.67
5(2)
3
5(2)
3
6(2)
5
CAPZA1
15(4)
15
68.40
11(11)
2
10(9)
3
12(11)
7
CTRC
9(1)
4
36.22
8(8)
1
Not Found

8(7)
3
DMRTA2
2(0)
2
1.00
1(1)
1
Not Found

2(2)
1
DPH2L2
12(1)
11
31.25
10(10)
7
12(11)
12
12(11)
14
EPHA2
20(1)
8
13.45
16(16)
1
17(17)
7
20(19)
8
EYA3
20(0)
9
11.40
15(15)
1
Not Found

21(20)
10
FBXO2
9(0)
6
13.67
9(8)
2
6(5)
3
9(8)
5
FCGR3B
7(0)
5
22.57
4(4)
1
Not Found

7(7)
6
FUCA1
11(3)
8
18.00
8(8)
2
Not Found

7(7)
2
GBP2
17(3)
8
27.82
12(12)
2
Not Found

26(14)
10
GMEB1
12(1)
5
16.67
9(9)
2
11(11)
3
11(11)
6
HNRPR
20(2)
38
45.70
16(15)
7
12(12)
7
21(18)
17
LGALS8
22(2)
25
16.00
12(11)
4
13(13)
4
27(19)
21
LRRN5
3(0)
3
3.00
5(3)
2
Not Found

5(3)
4
LYPLA2
15(0)
14
96.07
14(14)
6
Not Found

15(14)
14
MASP2
11(0)
5
7.00
11(11)
2
11(11)
5
11(11)
6
MOV10
35(4)
42
25.29
29(29)
7
24(23)
8
33(31)
21
NPPB
2(0)
1
30.50
2(2)
1
Not Found

3(2)
3
PAFAH2
18(3)
11
15.06
12(11)
2
13(13)
5
16(14)
8
PALMD
8(0)
9
35.63
7(7)
1
Not Found

9(8)
8
PEX10
12(1)
13
21.58
6(6)
1
10(10)
7
12(10)
11
PINK1
10(2)
15
40.20
7(7)
2
Not Found

9(8)
10
PTPRU
38(3)
15
12.89
20(20)
1
Not Found

35(35)
9
RHOC
17(3)
5
8.35
13(2)
7
15(1)
9
39(14)
31
SDC3
6(2)
5
5.33
4(3)
2
8(4)
5
9(5)
6
SDHB
11(0)
12
97.27
9(9)
3
Not Found

13(11)
11
SERPINC1
12(2)
7
18.75
8(8)
2
8(8)
3
16(10)
11
SFPQ
12(3)
11
74.75
9(9)
1
9(9)
3
17(9)
25
TARDBP
21(3)
20
29.38
15(13)
4
9(9)
4
18(16)
15
TCN2
13(1)
10
26.15
9(9)
2
12(12)
4
13(10)
11
TOR3A
15(2)
9
19.20
9(9)
4
11(11)
8
15(13)
12
VAMP3
5(0)
3
80.60
6(5)
2
6(5)
3
7(5)
10
Total
1009(94)
11.9
28.3
753(721)
2.3
495(461)
5.1
1194(905)
9.7

ASPIC results from a random sample of 64 human genes from Chromosome 1 compared to those from the ASAP, ASD and AceView resources. The first column reports the HUGO name of the examined gene. The ASPIC data include the total number of predicted introns (novel introns in brackets), the minimum number of compatible transcripts and the average number of ESTs supporting gene splices. Introns with 2 non canonical splices are accepted by ASPIC only if confirmed by at least two ESTs. For the other resources the number of predicted introns (in brackets those also predicted by ASPIC) and the minimum number of compatible transcripts are reported. Other resources: AceView (July 2003 and August 2004 releases), ASD (July 2004) and ASAP (July 2004).

Bonizzoni et al. BMC Bioinformatics 2005 6:244   doi:10.1186/1471-2105-6-244