BMC Bioinformatics

official impact factor 3.03

Open Access Highly Access Software

High-Throughput GoMiner, an 'industrial-strength' integrative gene ontology tool for interpretation of multiple-microarray experiments, with application to studies of Common Variable Immune Deficiency (CVID)

Barry R Zeeberg1, Haiying Qin2, Sudarshan Narasimhan3, Margot Sunshine3, Hong Cao3, David W Kane3, Mark Reimers3, Robert M Stephens4, David Bryant4, Stanley K Burt4, Eldad Elnekave5, Danielle M Hari5, Thomas A Wynn5, Charlotte Cunningham-Rundles6, Donn M Stewart2, David Nelson2 and John N Weinstein1*

Author Affiliations

1 Genomics and Bioinformatics Group, Laboratory of Molecular Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA

2 Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA

3 SRA International, 4300 Fair Lakes CT, Fairfax, VA 22033, USA

4 Advanced Biomedical Computing Center, National Cancer Institute at Frederick, SAIC Frederick, PO Box B, Frederick, MD, 21702, USA

5 Laboratory of Parasitic Disease, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA

6 The Mount Sinai Medical Center, 1425 Madison Avenue, New York, NY 10029, USA

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BMC Bioinformatics 2005, 6:168 doi:10.1186/1471-2105-6-168

Published: 5 July 2005

Additional files

Additional File 1:

Stability of Estimates of the False Discovery Rate

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Additional File 2:

Expression Data

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Additional File 3:

Output Files Generated from High-Throughput GoMiner

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Additional File 4:

Methodology Description

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Additional File 6:

Summary Report

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Additional File 7:

Gene Category Report

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Additional File 8:

CIM of Transcription Factors versus GO Categories

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Additional File 9:

Discussion of Results

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Additional File 5:

Instructions for Generating the CIMs in the Manuscript

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