BMC Bioinformatics

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High-Throughput GoMiner, an 'industrial-strength' integrative gene ontology tool for interpretation of multiple-microarray experiments, with application to studies of Common Variable Immune Deficiency (CVID)

Barry R Zeeberg, Haiying Qin, Sudarshan Narasimhan, Margot Sunshine, Hong Cao, David W Kane, Mark Reimers, Robert M Stephens, David Bryant, Stanley K Burt, Eldad Elnekave, Danielle M Hari, Thomas A Wynn, Charlotte Cunningham-Rundles, Donn M Stewart, David Nelson and John N Weinstein*

BMC Bioinformatics 2005, 6:168 doi:10.1186/1471-2105-6-168

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BioMed Central: 26 citations

Research   Open Access

Characterization of the abomasal transcriptome for mechanisms of resistance to gastrointestinal nematodes in cattle

Robert W Li, Manuela Rinaldi, Anthony V Capuco Veterinary Research 2011, 42:114 (30 November 2011)

Proceedings   Open Access

Building interpretable fuzzy models for high dimensional data analysis in cancer diagnosis

Zhenyu Wang, Vasile Palade BMC Genomics 2011, 12(Suppl 2):S5 (27 July 2011)

Proceedings   Open Access

Nonlinear gene cluster analysis with labeling for microarray gene expression data in organ development

Martin Ehler, Vinodh N Rajapakse, Barry R Zeeberg, Brian P Brooks, Jacob Brown, Wojciech Czaja, Robert F Bonner BMC Proceedings 2011, 5(Suppl 2):S3 (28 April 2011)

Research   Open Access Highly Accessed

A human functional protein interaction network and its application to cancer data analysis

Guanming Wu, Xin Feng, Lincoln Stein Genome Biology 2010, 11:R53 (19 May 2010)

A high-quality human functional protein interaction network is constructed. Its utility is demonstrated in the identification of cancer candidate genes.

Research article   Open Access

Predicting environmental chemical factors associated with disease-related gene expression data

Chirag J Patel, Atul J Butte BMC Medical Genomics 2010, 3:17 (6 May 2010)

Research article   Open Access

Glucocorticoids with different chemical structures but similar glucocorticoid receptor potency regulate subsets of common and unique genes in human trabecular meshwork cells

Alissar Nehmé, Edward K Lobenhofer, W Daniel Stamer, Jeffrey L Edelman BMC Medical Genomics 2009, 2:58 (10 September 2009)

Research article   Open Access

Interactome and Gene Ontology provide congruent yet subtly different views of a eukaryotic cell

Antonio Marco, Ignacio Marín BMC Systems Biology 2009, 3:69 (15 July 2009)

Software   Open Access Highly Accessed

Seeking unique and common biological themes in multiple gene lists or datasets: pathway pattern extraction pipeline for pathway-level comparative analysis

Ming Yi, Uma Mudunuri, Anney Che, Robert M Stephens BMC Bioinformatics 2009, 10:200 (29 June 2009)

Research   Open Access Highly Accessed

MicroRNA and gene expression patterns in the differentiation of human embryonic stem cells

Jiaqiang Ren, Ping Jin, Ena Wang, Francesco M Marincola, David F Stroncek Journal of Translational Medicine 2009, 7:20 (23 March 2009)

Research article   Open Access Highly Accessed

An Open Access Database of Genome-wide Association Results

Andrew D Johnson, Christopher J O'Donnell BMC Medical Genetics 2009, 10:6 (22 January 2009)

A new centralized open access database containing the results of 118 genome-wide association (GWA) studies shows considerable heterogeneity in the data and provides a potential resource for result sharing between a wide community of researchers.

Short Report   Open Access

Advanced spot quality analysis in two-colour microarray experiments

Mikalai Yatskou, Eugene Novikov, Guillaume Vetter, Arnaud Muller, Emmanuel Barillot, Laurent Vallar, Evelyne Friederich BMC Research Notes 2008, 1:80 (17 September 2008)

This article is part of a collection on Microarray normalization...

Method   Open Access Highly Accessed

Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype

Edward K Lobenhofer, J Todd Auman, Pamela E Blackshear, Gary A Boorman, Pierre R Bushel, Michael L Cunningham, Jennifer M Fostel, Kevin Gerrish, Alexandra N Heinloth, Richard D Irwin, David E Malarkey, B Alex Merrick, Stella O Sieber, Charles J Tucker, Sandra M Ward, Ralph E Wilson, Patrick Hurban, Raymond W Tennant, Richard S Paules Genome Biology 2008, 9:R100 (20 June 2008)

Histopathology, clinical chemistry, hematology and gene expression data were collected from the rat liver and blood after treatment with eight known hepatotoxins.

Research article   Open Access

Genes related to apoptosis predict necrosis of the liver as a phenotype observed in rats exposed to a compendium of hepatotoxicants

Lingkang Huang, Alexandra N Heinloth, Zhao-Bang Zeng, Richard S Paules, Pierre R Bushel BMC Genomics 2008, 9:288 (16 June 2008)

Methodology article   Open Access Highly Accessed

VennMaster: Area-proportional Euler diagrams for functional GO analysis of microarrays

Hans A Kestler, André Müller, Johann M Kraus, Malte Buchholz, Thomas M Gress, Hongfang Liu, David W Kane, Barry R Zeeberg, John N Weinstein BMC Bioinformatics 2008, 9:67 (29 January 2008)

Methodology article   Open Access

A general strategy to determine the congruence between a hierarchical and a non-hierarchical classification

Antonio Marco, Ignacio Marín BMC Bioinformatics 2007, 8:442 (15 November 2007)

Method   Open Access

The LeFE algorithm: embracing the complexity of gene expression in the interpretation of microarray data

Gabriel S Eichler, Mark Reimers, David Kane, John N Weinstein Genome Biology 2007, 8:R187 (10 September 2007)

The LeFE algorithm has been developed to address the complex, non-linear regulation of gene expression.

Software   Open Access Highly Accessed

The DAVID Gene Functional Classification Tool: a novel biological module-centric algorithm to functionally analyze large gene lists

Da Huang, Brad T Sherman, Qina Tan, Jack R Collins, W Gregory Alvord, Jean Roayaei, Robert Stephens, Michael W Baseler, H Clifford Lane, Richard A Lempicki Genome Biology 2007, 8:R183 (4 September 2007)

The DAVID gene functional classification tool uses a novel fuzzy clustering algorithm to condense a list of genes or associated biological terms into organized classes of related genes or biology, called biological modules.

Research article   Open Access

Gene expression changes associated with Barrett's esophagus and Barrett's-associated adenocarcinoma cell lines after acid or bile salt exposure

Ying Hao, Sumita Sood, George Triadafilopoulos, Jong Kim, Zheng Wang, Peyman Sahbaie, M Bishr Omary, Anson W Lowe BMC Gastroenterology 2007, 7:24 (27 June 2007)

Database   Open Access Highly Accessed

SpliceMiner: a high-throughput database implementation of the NCBI Evidence Viewer for microarray splice variant analysis

Ari B Kahn, Michael C Ryan, Hongfang Liu, Barry R Zeeberg, D Curtis Jamison, John N Weinstein BMC Bioinformatics 2007, 8:75 (5 March 2007)

Software   Open Access Highly Accessed

FUNC: a package for detecting significant associations between gene sets and ontological annotations

Kay Prüfer, Bjoern Muetzel, Hong-Hai Do, Gunter Weiss, Philipp Khaitovich, Erhard Rahm, Svante Pääbo, Michael Lachmann, Wolfgang Enard BMC Bioinformatics 2007, 8:41 (6 February 2007)

Software   Open Access Highly Accessed

PageMan: An interactive ontology tool to generate, display, and annotate overview graphs for profiling experiments

Björn Usadel, Axel Nagel, Dirk Steinhauser, Yves Gibon, Oliver E Bläsing, Henning Redestig, Nese Sreenivasulu, Leonard Krall, Matthew A Hannah, Fabien Poree, Alisdair R Fernie, Mark Stitt BMC Bioinformatics 2006, 7:535 (18 December 2006)

Research article   Open Access Highly Accessed

Mining expressed sequence tags identifies cancer markers of clinical interest

Fabien Campagne, Lucy Skrabanek BMC Bioinformatics 2006, 7:481 (1 November 2006)

Proceedings   Open Access

GOFFA: Gene Ontology For Functional Analysis – A FDA Gene Ontology Tool for Analysis of Genomic and Proteomic Data

Hongmei Sun, Hong Fang, Tao Chen, Roger Perkins, Weida Tong BMC Bioinformatics 2006, 7(Suppl 2):S23 (26 September 2006)

Methodology article   Open Access

Cluster analysis of protein array results via similarity of Gene Ontology annotation

Cheryl Wolting, C Jane McGlade, David Tritchler BMC Bioinformatics 2006, 7:338 (12 July 2006)

Software   Open Access Highly Accessed

STEM: a tool for the analysis of short time series gene expression data

Jason Ernst, Ziv Bar-Joseph BMC Bioinformatics 2006, 7:191 (5 April 2006)

Research   Open Access Highly Accessed

The molecular portrait of in vitro growth by meta-analysis of gene-expression profiles

Rickard Sandberg, Ingemar Ernberg Genome Biology 2005, 6:R65 (27 July 2005)

A meta analysis comparing 60 tumor cell lines, 135 normal tissue samples and 176 tumor tissue samples in humans shows significant differential expression between cell lines and tissues of around 30% of the 7,000 genes analyzed.