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Open AccessMethodology article

The effects of normalization on the correlation structure of microarray data

Xing Qiu1 email, Andrew I Brooks2 email, Lev Klebanov1,3 email and Andrei Yakovlev1 email

1Department of Biostatistics and Computational Biology, University of Rochester, New York 14642, USA

2Functional Genomics Center, University of Rochester, 601 Elmwood Avenue, Rochester, New York 14642, USA

3Department of Probability and Statistics, Charles University, Sokolovska 83, Praha-8, CZ-18675, Czech Republic

author email corresponding author email

BMC Bioinformatics 2005, 6:120doi:10.1186/1471-2105-6-120

Published: 16 May 2005

Additional files

Additional File 1:

The effect of normalization with non-overlapping pairs of genes;

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Additional File 2:

The effect of normalization procedures on the correlation structure of simulated data;

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Additional File 3:

The effect of the quantile normalization on the distribution of the t-statistics across genes.

Format: PDF Size: 59KB Download file

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