BMC Bioinformatics

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A Bayesian method for identifying missing enzymes in predicted metabolic pathway databases

Michelle L Green* and Peter D Karp

BMC Bioinformatics 2004, 5:76 doi:10.1186/1471-2105-5-76

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BioMed Central: 14 citations

Proceedings   Open Access

Metabolic network alignment in large scale by network compression

Ferhat Ay, Michael Dang, Tamer Kahveci BMC Bioinformatics 2012, 13(Suppl 3):S2 (21 March 2012)

Research   Open Access

Synergistic use of plant-prokaryote comparative genomics for functional annotations

Svetlana Gerdes, Basma El Yacoubi, Marc Bailly, Ian K Blaby, Crysten E Blaby-Haas, Linda Jeanguenin, Aurora Lara-Núñez, Anne Pribat, Jeffrey C Waller, Andreas Wilke, Ross Overbeek, Andrew D Hanson, Valérie de Crécy-Lagard BMC Genomics 2011, 12(Suppl 1):S2 (15 June 2011)

Research   Open Access

Genome-wide discovery of missing genes in biological pathways of prokaryotes

Yong Chen, Fenglou Mao, Guojun Li, Ying Xu BMC Bioinformatics 2011, 12(Suppl 1):S1 (15 February 2011)

Research   Open Access Highly Accessed

The conservation and evolutionary modularity of metabolism

José M Peregrín-Alvarez, Chris Sanford, John Parkinson Genome Biology 2009, 10:R63 (12 June 2009)

A novel evolutionary analysis of metabolic networks across 26 taxa reveals a highly-conserved but flexible core of metabolic enzymes.

Research article   Open Access Highly Accessed

Analysis of Aspergillus nidulans metabolism at the genome-scale

Helga David, İlknur Ş Özçelik, Gerald Hofmann, Jens Nielsen BMC Genomics 2008, 9:163 (11 April 2008)

Methodology article   Open Access

Optimization based automated curation of metabolic reconstructions

Vinay Satish Kumar, Madhukar S Dasika, Costas D Maranas BMC Bioinformatics 2007, 8:212 (20 June 2007)

Research article   Open Access Highly Accessed

Toward the automated generation of genome-scale metabolic networks in the SEED

Matthew DeJongh, Kevin Formsma, Paul Boillot, John Gould, Matthew Rycenga, Aaron Best BMC Bioinformatics 2007, 8:139 (26 April 2007)

Research article   Open Access

Systematic assignment of thermodynamic constraints in metabolic network models

Anne Kümmel, Sven Panke, Matthias Heinemann BMC Bioinformatics 2006, 7:512 (23 November 2006)

Research article   Open Access

A case study in pathway knowledgebase verification

Stephen A Racunas, Nigam H Shah, Nina V Fedoroff BMC Bioinformatics 2006, 7:196 (8 April 2006)

Methodology article   Open Access

Identifying metabolic enzymes with multiple types of association evidence

Peter Kharchenko, Lifeng Chen, Yoav Freund, Dennis Vitkup, George M Church BMC Bioinformatics 2006, 7:177 (29 March 2006)

Software   Open Access Highly Accessed

BioWarehouse: a bioinformatics database warehouse toolkit

Thomas J Lee, Yannick Pouliot, Valerie Wagner, Priyanka Gupta, David WJ Stringer-Calvert, Jessica D Tenenbaum, Peter D Karp BMC Bioinformatics 2006, 7:170 (23 March 2006)

Method   Open Access Highly Accessed

Predicting genes for orphan metabolic activities using phylogenetic profiles

Lifeng Chen, Dennis Vitkup Genome Biology 2006, 7:R17 (15 February 2006)

A method that combines local structure of a metabolic network with phylogenetic profiles is described and used to assign genes to orphan metabolic activities in yeast and Escherichia coli.

Methodology article   Open Access

Automation of gene assignments to metabolic pathways using high-throughput expression data

Liviu Popescu, Golan Yona BMC Bioinformatics 2005, 6:217 (31 August 2005)

Research   Open Access Highly Accessed

Computational prediction of human metabolic pathways from the complete human genome

Pedro Romero, Jonathan Wagg, Michelle L Green, Dale Kaiser, Markus Krummenacker, Peter D Karp Genome Biology 2004, 6:R2 (22 December 2004)

A computation pathway analysis of the human genome is presented that assigns enzymes encoded by the genome to predicted metabolic pathways. This analysis provides a genome-based view of human nutrition.