BMC Bioinformatics

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Benchmarking tools for the alignment of functional noncoding DNA

Daniel A Pollard, Casey M Bergman*, Jens Stoye, Susan E Celniker and Michael B Eisen

BMC Bioinformatics 2004, 5:6 doi:10.1186/1471-2105-5-6

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BioMed Central: 24 citations

Methodology article   Open Access Highly Accessed

A genome alignment algorithm based on compression

Minh Cao, Trevor I Dix, Lloyd Allison BMC Bioinformatics 2010, 11:599 (16 December 2010)

Research article   Open Access Highly Accessed

Cgaln: fast and space-efficient whole-genome alignment

Ryuichiro Nakato, Osamu Gotoh BMC Bioinformatics 2010, 11:224 (30 April 2010)

Research article   Open Access Highly Accessed

Towards realistic benchmarks for multiple alignments of non-coding sequences

Jaebum Kim, Saurabh Sinha BMC Bioinformatics 2010, 11:54 (26 January 2010)

Software   Open Access Highly Accessed

Tools for simulating evolution of aligned genomic regions with integrated parameter estimation

Avinash Varadarajan, Robert K Bradley, Ian H Holmes Genome Biology 2008, 9:R147 (8 October 2008)

Three tools for simulating genome evolution are presented: for neutrally evolving DNA, for phylogenetic context-free grammars and for richly structured syntenic blocks of genome sequence.

Software   Open Access

ReAlignerV: Web-based genomic alignment tool with high specificity and robustness estimated by species-specific insertion sequences

Hisakazu Iwama, Yukio Hori, Kensuke Matsumoto, Koji Murao, Toshihiko Ishida BMC Bioinformatics 2008, 9:112 (22 February 2008)

Research article   Open Access

Evaluation of phylogenetic footprint discovery for predicting bacterial cis-regulatory elements and revealing their evolution

Rekin's Janky, Jacques van Helden BMC Bioinformatics 2008, 9:37 (23 January 2008)

Research article   Open Access Highly Accessed

How accurately is ncRNA aligned within whole-genome multiple alignments?

Adrienne X Wang, Walter L Ruzzo, Martin Tompa BMC Bioinformatics 2007, 8:417 (26 October 2007)

Research   Open Access Highly Accessed

Phylogenetic simulation of promoter evolution: estimation and modeling of binding site turnover events and assessment of their impact on alignment tools

Weichun Huang, Joseph R Nevins, Uwe Ohler Genome Biology 2007, 8:R225 (24 October 2007)

Phylogenetic simulation of promoter evolution were used to analyze functional site turnover in regulatory sequences.

Research   Open Access Highly Accessed

Large-scale analysis of transcriptional cis-regulatory modules reveals both common features and distinct subclasses

Long Li, Qianqian Zhu, Xin He, Saurabh Sinha, Marc S Halfon Genome Biology 2007, 8:R101 (5 June 2007)

Analysis of 280 experimentally-verified cis-regulatory modules from Drosophila reveal features both common to all and unique to distinct subclasses of modules.

Research article   Open Access Highly Accessed

Considerations in the identification of functional RNA structural elements in genomic alignments

Tomas Babak, Benjamin J Blencowe, Timothy R Hughes BMC Bioinformatics 2007, 8:33 (30 January 2007)

Search tools perform poorly at finding noncoding RNAs on a test set of known ncRNAs for which the sequences are randomly shuffled, although a combination of conservation and thermodynamic stability has promise for ncRNA detection.

Software   Open Access Highly Accessed

CGAT: a comparative genome analysis tool for visualizing alignments in the analysis of complex evolutionary changes between closely related genomes

Ikuo Uchiyama, Toshio Higuchi, Ichizo Kobayashi BMC Bioinformatics 2006, 7:472 (24 October 2006)

Research article   Open Access

Detecting the limits of regulatory element conservation and divergence estimation using pairwise and multiple alignments

Daniel A Pollard, Alan M Moses, Venky N Iyer, Michael B Eisen BMC Bioinformatics 2006, 7:376 (14 August 2006)

Methodology article   Open Access

MCALIGN2: Faster, accurate global pairwise alignment of non-coding DNA sequences based on explicit models of indel evolution

Jun Wang, Peter D Keightley, Toby Johnson BMC Bioinformatics 2006, 7:292 (8 June 2006)

Research   Open Access Highly Accessed

Multiple sequence alignment with user-defined anchor points

Burkhard Morgenstern, Sonja J Prohaska, Dirk Pöhler, Peter F Stadler Algorithms for Molecular Biology 2006, 1:6 (19 April 2006)

Software   Open Access

SinicView: A visualization environment for comparisons of multiple nucleotide sequence alignment tools

Arthur Shih, DT Lee, Laurent Lin, Chin-Lin Peng, Shiang-Heng Chen, Yu-Wei Wu, Chun-Yi Wong, Meng-Yuan Chou, Tze-Chang Shiao, Mu-Fen Hsieh BMC Bioinformatics 2006, 7:103 (2 March 2006)

Research article   Open Access

NemaFootPrinter: a web based software for the identification of conserved non-coding genome sequence regions between C. elegans and C. briggsae

Davide Rambaldi, Alessandro Guffanti, Paolo Morandi, Giuseppe Cassata BMC Bioinformatics 2005, 6(Suppl 4):S22 (1 December 2005)

Research article   Open Access Highly Accessed

Multiple sequence alignment accuracy and evolutionary distance estimation

Michael S Rosenberg BMC Bioinformatics 2005, 6:278 (23 November 2005)

Software   Open Access

Genomic multiple sequence alignments: refinement using a genetic algorithm

Chunlin Wang, Elliot J Lefkowitz BMC Bioinformatics 2005, 6:200 (8 August 2005)

Research article   Open Access

Evolutionary distance estimation and fidelity of pair wise sequence alignment

Michael S Rosenberg BMC Bioinformatics 2005, 6:102 (19 April 2005)

Research article   Open Access Highly Accessed

DIALIGN-T: An improved algorithm for segment-based multiple sequence alignment

Amarendran R Subramanian, Jan Weyer-Menkhoff, Michael Kaufmann, Burkhard Morgenstern BMC Bioinformatics 2005, 6:66 (22 March 2005)

Method   Open Access Highly Accessed

MONKEY: identifying conserved transcription-factor binding sites in multiple alignments using a binding site-specific evolutionary model

Alan M Moses, Derek Y Chiang, Daniel A Pollard, Venky N Iyer, Michael B Eisen Genome Biology 2004, 5:R98 (30 November 2004)

MONKEY is a new method for identifying conserved transcription-factor binding sites from multiple-sequence alignments.

Software   Open Access

DIALIGN P: Fast pair-wise and multiple sequence alignment using parallel processors

Martin Schmollinger, Kay Nieselt, Michael Kaufmann, Burkhard Morgenstern BMC Bioinformatics 2004, 5:128 (9 September 2004)

Research   Open Access Highly Accessed

Computational identification of developmental enhancers: conservation and function of transcription factor binding-site clusters in Drosophila melanogaster and Drosophila pseudoobscura

Benjamin P Berman, Barret D Pfeiffer, Todd R Laverty, Steven L Salzberg, Gerald M Rubin, Michael B Eisen, Susan E Celniker Genome Biology 2004, 5:R61 (20 August 2004)

27 predicted gene-regulatory regions in the Drosophila melanogaster genome were analyzed in vivo, confirming 15 active enhancer regions. A comparison with Drosophila pseudoobscura sequences revealed that conservation of binding-site clusters accurately discriminates functional regions from non-functional ones.

Correction   Open Access

Correction: Benchmarking tools for the alignment of functional noncoding DNA

DA Pollard, CM Bergman, J Stoye, SE Celniker, MB Eisen BMC Bioinformatics 2004, 5:73 (8 June 2004)