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Gene prediction using the Self-Organizing Map: automatic generation of multiple gene models

Shaun Mahony1*, James O McInerney2, Terry J Smith1 and Aaron Golden3

Author Affiliations

1 National Centre for Biomedical Engineering Science, NUI, Galway, Galway, Ireland

2 Bioinformatics and Pharmacogenomics Laboratory, NUI, Maynooth, Co. Kildare, Ireland

3 Department of Information Technology, NUI, Galway, Galway, Ireland

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BMC Bioinformatics 2004, 5:23  doi:10.1186/1471-2105-5-23

Published: 5 March 2004

Abstract

Background

Many current gene prediction methods use only one model to represent protein-coding regions in a genome, and so are less likely to predict the location of genes that have an atypical sequence composition. It is likely that future improvements in gene finding will involve the development of methods that can adequately deal with intra-genomic compositional variation.

Results

This work explores a new approach to gene-prediction, based on the Self-Organizing Map, which has the ability to automatically identify multiple gene models within a genome. The current implementation, named RescueNet, uses relative synonymous codon usage as the indicator of protein-coding potential.

Conclusions

While its raw accuracy rate can be less than other methods, RescueNet consistently identifies some genes that other methods do not, and should therefore be of interest to gene-prediction software developers and genome annotation teams alike. RescueNet is recommended for use in conjunction with, or as a complement to, other gene prediction methods.