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Kamesh Munagala*, Robert Tibshirani and Patrick O Brown
Corresponding author: Kamesh Munagala firstname.lastname@example.org
BMC Bioinformatics 2004, 5:21 doi:10.1186/1471-2105-5-21
(2004-03-10 07:31) Private. Specialist in Blood, Gastrointestinal, and Metabolic Diseases. Researcher
in Biophysical Semeiotics.
in the war against cancers, we must especially to study a clinical tool that helps
“all” doctors in bed side recognizing, in apparently healthy individuals,
genetical errors, including hyperinsulinemia-insulinresistance, melatonine deficiency,
metabolic disorders, prevalence of stress axis, a.s.o., which either bring about or
aggravate chromosomal aberrations, n-DNA as well as m-DNA as those observed in cancer
cells. In fact, our target can be reached hopefully if “all” doctors are
able to ascertain or at least suspect at the bed-side in apparently health persons
chromosomal aberrations,particularly in m-DNA, before cancer on-set (1)(See: Oncological
Terrain, in my web site, HONCode ID, N. 233736, www.semeioticabiofisica.it).
As a working hypothesis, I thought previously that all chromosomal alterations, of
whatever nature, n-DNA and m-DNA, are necessarily accompanied with similar microvascular
modification of the local microcirculatory bed, both structural and functional in
nature, in subject involved by abnormalities of pschyco-neuro-endocrinological-immune
system. As a matter of fact, both genetical and environmental factors induce contemporaneously
parenchymal and microvascular cells alterations, according to the well-known concept
ofTiscedorf’s “Angiobiotopie”. For instance, a family of molecules
called cyclins was descovered. It is through changes in the production of cyclins
during the cell cycle that the activity of the genes controlling it are themselves
regulated. All these events (control, regulation a.s.o.), however, can happen only
by means of normal changes in local microcirculation, i.e., in information-material-energy
supply to tissue. Now, fortunately, thanks to Biophysical Semeiotics (See the above
cited-site), we can evaluate clinically microcirculatory bed structure and function
in a precise manner (1-5).
Based on 46-year-long "clinical" experience, the decline in cancer rates all over
the world could be more intense if scientists will think over and discuss the possibility
that exists the "Oncological Terrain". As a matter of fact, e.g., not all smokers
are involved by pulmonary cancer, as well as not all people with chronic hepatitis
will die of hepatocarcinoma. On the other side, in some families malignancies occur
more frequently than in others. Actually, as I described in the above-mentioned papers,
there are other causes that accounts for the reason of existence of the oncological
“real” risk, i.e. oncological terrain.
At this point, the first question is the following: "What does characterize oncological
terrain from the "clinical" point of view?". In fact, in order to achieve efficacious
cancer prevention on very large scale it is unavoidable that the modifications occurring
in the biological controll system could be easily, promptly, and “quantitatively”
ascertained and properly evaluated with the aid of a “clinical” method,
i.e. by the use of a sthetoscope, and certainly without application of sophysticated
semeiotics, that does not apply in all individuals, on a very large scale, and, moreover,
only a few doctors can utilize them.
If it is possible to answer this first question, a second one immediately follows:
"The oncological terrain which certanly can be induced, is also in some way reversible?"
It is urgent and necessary to know if the oncological terrain can be reversed, i.e.
if it can totally or greatly disappeare, with the aid of drugs or diet, ethymologically
speaking, which exert a favourable influence on the characteristic modifications of
the psicho-neuro-endocrine- immunological system, that represent “oncological
terrain”. My answers to these questions are readable in my site (5).
The war against cancer will be fortunately won if all doctor are going to recognize,
with the aid of a stethoscope, individual apparently health but positive for “oncological
terrain”, particularly intense in a well defined tissue region, who have to
undergo immediately to proper diet, ethymologically speaking, and drugs, in some cases.
Unfortunately, change in Medicine is an up-hill task! Moreover, in the discussion
between theories the power of the antagonists is more important than that of the ideas.
But, fortunately, ideas go on and on, and on..., although slowly. Hopenly, somebody
will spread this interesting knowledge about "oncological terrain", like BMJ.com.
Stagnaro Sergio MD., Member NYAS
Riva Trigoso (Genoa) Italy.
1) Stagnaro-Neri M., Stagnaro S. Introduzione alla Semeiotica Biofisica. Il Terreno
Oncologico. Travel Factory Ed., Rome, in press.
2) Stagnaro-Neri M., Stagnaro S., Semeiotica Biofisica del torace, della circolazione
ematica e dell’anticorpopoiesi acuta e cronica. Acta Med. Medit. 13, 25 1997
3) Stagnaro-Neri M., Stagnaro S., Semeiotica Biofisica: la manovra di Ferrero-Marigo
nella diagnosi clinica della iperinsulinemia-insulino resistenza. Acta Med. Medit.
13, 125 1997
4) Stagnaro-Neri M., Stagnaro S., Semeiotica Biofisica: valutazione clinica del picco
precoce della secrezione insulinica di base e dopo stimolazione tiroidea, surrenalica,
con glucagone endogeno e dopo attivazione del sistema renina-angiotesina circolante
e tessutale – Acta Med. Medit. 13, 99.
5) Stagnaro S., Sindrome percusso-ascoltatoria di Iperfunzione del Sistema Reticolo-Istiocitario.
Min. Med. 74, 479, 1983 (Pub-Med indexed for Medline)
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