Co-regulation vs. Co-expression and Functional Similarity as Defined by Minimum Node Count A, B and C were created using the biological process, molecular function and cellular component ontologies, respectively. For each of the three ontologies, the gene pairs are divided into two groups – those with minimum node counts less than the 10th percentile and greater than the 10th percentile. At higher levels of correlation in expression profile, gene pairs with greater functional similarity are more likely to share a common transcription factor binder.
Allocco et al. BMC Bioinformatics 2004 5:18 doi:10.1186/1471-2105-5-18