Co-regulation vs. Functional Similarity as Defined by Level of GO Term Match BP, MF and CC refer to the biological process, molecular function and cellular component ontologies, respectively. A) The number of gene pairs which have matching GO terms decreases as the strictness of the required match increases. B) The fraction of gene pairs sharing a common transcription factor binder increases as the level of functional similarity increases, particularly for the BP and MF ontologies.
Allocco et al. BMC Bioinformatics 2004 5:18 doi:10.1186/1471-2105-5-18