ROC plots. We use ROC (receiver operating characteristic) plots to simultaneously display both sensitivity and selectivity for plans A, B and C respectively. Accuracies of the MFE methods (MFold, RNAFold and SFold) are shown in each plot to provide a base-line. Points on the line X = Y are as sensitive as they are selective, points below this line indicates a greater selectivity, points above indicate greater sensitivity. Points below the line X = 100 - Y are worse than "random" assignments; Assuming base-pairs are independent of each other (this is false for base-pairing). Points in the top right corner are "perfect" predictions. Interestingly many algorithms form characteristic clusters in these plots. Where the variance is sufficiently small these have been indicated with a closed curve.
Gardner and Giegerich BMC Bioinformatics 2004 5:140 doi:10.1186/1471-2105-5-140