|
Minimum inhibitory concentration (MIC) of rifampin and associated variable amino acids in positions 511–533 of the β subunit of RNA polymerase of Mycobacterium tuberculosis [2–4]. |
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| MIC (μg/ml) |
No. of Isolates |
No. of Isolates with Differences |
Amino Acid Differences from Consensus (No. of Isolates) |
|
|
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| 0.0625 |
48 |
1 |
515:V(1) |
| 0.125 |
2 |
0 |
|
| 0.25 |
2 |
0 |
|
| < 0.39 |
13 |
2 |
521:P(1), 533:P(1) |
| 0.5 |
2 |
1 |
533:P(1) |
| 1 |
3 |
1 |
533:P(1) |
| 2 |
2 |
1 |
511:R and 512:T(1) |
| 4 |
2 |
1 |
516:V(1) |
| 8 |
6 |
5 |
516:V(1), 526:G(1), 526:L(2), 526:Q and 533:P(1) |
| 12.5 |
3 |
3 |
514:L and 516:V(1), 533:P(2) |
| 16 |
3 |
3 |
526:L(1), 526:N(1), 529:K(1) |
| 32 |
1 |
0 |
|
| > 32 |
15 |
15 |
511:R and 516:Y(1), 513:K(1), 513:L(1), 526:D(2), 526:Y(4), 531:L(4), 531:W(1), 533:P(1) |
| 50 |
1 |
1 |
531:L(1) |
| 64 |
7 |
7 |
531:L(7) |
| 100 |
1 |
1 |
531:L(1) |
| 128 |
19 |
19 |
513:L(1), 516:Y(1), 526Y(1), 531L(16) |
| 200 |
1 |
1 |
526:D(1) |
| > 200 |
7 |
7 |
513:L(1), 516:A and 526:D(1), 526:P(1), 526:Y(2), 531:L(2) |
| 256 |
13 |
13 |
513:K(1), 516:Y and 526:N(1), 526:P(1), 531:L(10) |
| 512 |
18 |
18 |
526:P(4), 526:R(2), 526:Y(3), 531:L(7), 531:W(2) |
| > 512 |
4 |
4 |
516:Y(1), 526:D(1), 526:P(1), 531:W(1) |
Cummings and Segal BMC Bioinformatics 2004 5:137 doi:10.1186/1471-2105-5-137 |
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