Table 1

Minimum inhibitory concentration (MIC) of rifampin and associated variable amino acids in positions 511–533 of the β subunit of RNA polymerase of Mycobacterium tuberculosis [2–4].

MIC (μg/ml)

No. of Isolates

No. of Isolates

with Differences

Amino Acid Differences from Consensus (No. of Isolates)

0.0625

48

1

515:V(1)

0.125

2

0

0.25

2

0

< 0.39

13

2

521:P(1), 533:P(1)

0.5

2

1

533:P(1)

1

3

1

533:P(1)

2

2

1

511:R and 512:T(1)

4

2

1

516:V(1)

8

6

5

516:V(1), 526:G(1), 526:L(2), 526:Q and 533:P(1)

12.5

3

3

514:L and 516:V(1), 533:P(2)

16

3

3

526:L(1), 526:N(1), 529:K(1)

32

1

0

> 32

15

15

511:R and 516:Y(1), 513:K(1), 513:L(1), 526:D(2), 526:Y(4), 531:L(4), 531:W(1), 533:P(1)

50

1

1

531:L(1)

64

7

7

531:L(7)

100

1

1

531:L(1)

128

19

19

513:L(1), 516:Y(1), 526Y(1), 531L(16)

200

1

1

526:D(1)

> 200

7

7

513:L(1), 516:A and 526:D(1), 526:P(1), 526:Y(2), 531:L(2)

256

13

13

513:K(1), 516:Y and 526:N(1), 526:P(1), 531:L(10)

512

18

18

526:P(4), 526:R(2), 526:Y(3), 531:L(7), 531:W(2)

> 512

4

4

516:Y(1), 526:D(1), 526:P(1), 531:W(1)

Cummings and Segal BMC Bioinformatics 2004 5:137   doi:10.1186/1471-2105-5-137