BMC Bioinformatics

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Open Access

Handling multiple testing while interpreting microarrays with the Gene Ontology Database

Michael V Osier*, Hongyu Zhao and Kei-Hoi Cheung

BMC Bioinformatics 2004, 5:124 doi:10.1186/1471-2105-5-124

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Gene expression changes following extinction testing in a heroin behavioral incubation model

Kara L Kuntz-Melcavage, Robert M Brucklacher, Patricia S Grigson, Willard M Freeman, Kent E Vrana BMC Neuroscience 2009, 10:95 (7 August 2009)

Heroin exposure, followed by abstinence then cues that induce drug-seeking behavior, leads to changes in gene expression in the medial prefrontal cortex of rats, suggesting these genes may be important in relapse.

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FUNC: a package for detecting significant associations between gene sets and ontological annotations

Kay Prüfer, Bjoern Muetzel, Hong-Hai Do, Gunter Weiss, Philipp Khaitovich, Erhard Rahm, Svante Pääbo, Michael Lachmann, Wolfgang Enard BMC Bioinformatics 2007, 8:41 (6 February 2007)

Software   Open Access

GO-2D: identifying 2-dimensional cellular-localized functional modules in Gene Ontology

Jing Zhu, Jing Wang, Zheng Guo, Min Zhang, Da Yang, Yanhui Li, Dong Wang, Guohua Xiao BMC Genomics 2007, 8:30 (24 January 2007)

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BayGO: Bayesian analysis of ontology term enrichment in microarray data

Ricardo ZN Vêncio, Tie Koide, Suely L Gomes, Carlos A de B Pereira BMC Bioinformatics 2006, 7:86 (23 February 2006)

Searching for enriched ontology terms in microarray data is improved by an innovative, freely available Bayesian approach that accounts for genes missed in the analysis, offering an advance on 'frequentist' approaches.