Figure 1.

Progressive alignment. Sequences are assigned to the leaves of a binary tree. At each internal (i.e., non-leaf) node, the two child profiles are aligned using profile-profile alignment (see Figure 2). Indels introduced at each node are indicated by shaded background.

Edgar BMC Bioinformatics 2004 5:113   doi:10.1186/1471-2105-5-113
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