Figure 1.

Primary collaboration relationships represented in MuTrack. This is a partial depiction of the collaborative effort to study genome-scale mouse mutagenesis and reveals the complexity of distributed collaborations. Mice are mutagenized at two separate institutions within the state of Tennessee and bred according to a scheme that produces visible, non-visible, or lethal mutations. Mice that do not present gross phenotype anomalies are processed throughout the state by experts in mouse genetics, behavior, physiology and aging, among other fields. MuTrack is responsible for tracking the complex breeding schemes, the physical location, health and test status of all mice in the testing pipeline, experimental data collection from each testing domain, real-time analysis of results, and free-form observations about pedigrees of interest. Not shown, but also within the scope of MuTrack, is the secondary screening template of possible mutants involving other locations (Case Western University, Meharry Medical College) and the system to distribute heritable mouse mutants to the mouse research community.

Baker et al. BMC Bioinformatics 2004 5:11   doi:10.1186/1471-2105-5-11
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