Figure 5.

The sum of distance, the sum of all the shortest paths from a superfamily to every other superfamily in the network. Blue indicates low sum of distance (central) and red high sum of distance (rim). The 6 superfamilies with lowest sum of distance are c.37.1, P-loop containing nucleotide triphosphate hydrolases; b.1.1, Immunoglobulin; d.153.1, N-terminal nucleophile aminohydrolases (Ntn hydrolases); a.118.1, ARM repeat; c.26.1, Nucleotidylyl transferase; a.4.5, Winged helix DNA-binding domain