Table 1

Kelch-repeat proteins of H. sapiens

Architecture
Domain organisation
GenBank Accession
Alternate name
Amino Acids
Chromosome localisation
Reference

BTB/kelch







BTB/K5(C)
NP_055666
KIAA0469
539
1p36.23
75

BTB/K5(C)
NP_006054
Sarcosin, KLP23, Krp1
606 +
2q31.1
76, 77

BTB/K5(C)
AAH10437

558
2q31.1
78

BTB/K5(C)
NP_115894
Tcell activation kelch-repeat protein
575
3p14
79

BTB/K5(C)
NP_689606
Sarcosynapsin
472
3p21.32


BTB/K5(C)
NP_060114

412
3q27.3


BTB/K5(C)
XP_291224
KIAA1489
623
7p14.3


BTB/K5(C)
XP_063481 *

819
14q11.1


BTB/K5(C)
XP_171687 *

458 $
15q21.2


BTB/K6(C)
NP_005888
IPP
584
1p32
80

BTB/K6(C)
NP_055273
Kelch motif-containing protein, KLX
609
1q24.1-24.3


BTB/K6(C)
NP_006460
NS1-binding protein, Nd1 orthologue
642
1q25.1
81, 82

BTB/K6(C)
NP_067646
Kelch-like protein C3IP1
568
1q31.3


BTB/K6(C)
BAB67814
KIAA1921
545
2p23.2
83

BTB/K6(C)
XP_292990

649
2q37.3


BTB/K6(C)
XP_093813 *

585
3q21.3


BTB/K6(C)
BAB93503

509
3p21.31


BTB/K6(C)
NP_569713
KLHL6
610
3q27.3
84, 85

BTB/K6(C)
NP_057074
KLHL5, lymphocyte activation-associated protein
734 @
4p15.1
86

BTB/K6(C)
NP_009177
Mayven, KLP2
593
4q21.2
87

BTB/K6(C)
NP_065854
KLHL8
620
4q21.3
88

BTB/K6(C)
NP_003624
ENC-1, Nrp/b
589
5q12-q13.3
89, 90

BTB/K6(C)
NP_059111
KLHL3
587
5q31
91, 92

BTB/K6(C)
CAC16284

634
6p12.1


BTB/K6(C)
NP_443136
KIAA1900
620
6q16.3
93

BTB/K6(C)
NP_061334

564
7q15.3


BTB/K6(C)
NP_055682
KIAA0711
623
8p23.2
94

BTB/K6(?)
XP_294387 *

649
8q24.13


BTB/K6(C)
NP_005884
Calicin
588
9p11.2
95

BTB/K6(C)
NP_061335
KIAA1354
617
9p22
88

BTB/K6(C)
NP_060565

518
11p11.12


BTB/K6(C)
AAH42952

431(a)
11q13.3


BTB/K6(C)
NP_689646

608
11q22.3


BTB/K6(C)
XP_044836

505
12q11.23


BTB/K6(C)
NP_115514

684
13q13.3
96

BTB/K6(C)
NP_065917
KLHL1
748
13q21
97

BTB/K6(C)
XP_058629 *

309(b)
14q21.1


BTB/K6(C)
NP_071925

589
15q25.2


BTB/K6(C)
NP_079007

616
16q23.3


BTB/K6(C)
NP_071324
gigaxonin
597
16q24.1
98

BTB/K6(C)
NP_689680
KLHL10
614
17q21.2


BTB/K6(C)
NP_060613

708
17q21.2


BTB/K6(C)
spQ9P2G3 *
KIAA1384
628
18q12.1
88

BTB/K6(C)
NP_060786

615
19p13.11


BTB/K6(C)
NP_036421
Keap1
624
19p13.2
98, 99

BTB/K6(C)
NP_116164

634
22q11.21


BTB/K6(C)
NP_695002

644
Xp22.13


BTB/K6(C)
NP_476503
KLHL4
720
Xq21.3
100

BTB/K6(C)
XP_040383
KIAA1677
604
Xq22.1-q21


BTB/K6(C)
spQ9P2N7
KIAA1309
639
Xq23-q24


K6/BTBx2(N)
NP_006758
LZTR-1 ^
552
22q11.21
69
Discoidin/kelch







DD/K6(N)
NP_037387 *
muskelin
735
7q32
71
F-box/kelch







F-box/K5(N)
XP_048774
KIAA1332
717
1p36.13

LCM/kelch







LCM/K6(?)
NP_055608 *
p21Waf/CIPpromoter-binding protein
686
15q14
26
Kelch and PHD







K6/u/PHD(N)
NP_000527 *
RAG-2
527
11p13
16
Kelch and multidomain







K6/HCF/FNIII
NP_005325
Host cell factor-1(N)
1938
Xq28
30

CUB/DSL/K4?
CAC12966

510
10q26.11


K5/CL(C)
BAA25460
KIAA0543
1011
10q26
101

K6/FNIII(N)
NP_037452
Host cell factor-2
792
12q23.3
31

CUB/K6/E(N)
PIRT00209
MEGF8, pregnancy-specific β 1 glycoprotein
1737 +
19q12
102

CB/K6/CL(N)
NP_647537 *
Attractin, mahogany
1198, 1429 +
20p13
27–29
Kelch and unique







u/K6(C)
NP_689588

559
1p36.13


K6/u(N,?)
NP_060036

520
16q24.3


u/K5(C)
NP_612442

495
22q13.33

Propeller only







K7(N)
NP_060673

350
1q32.1


K7(N)
NP_775817 *

354
3p21.21


K6(N,?)
NP_476502
PEAS, TIM
382
6p21.1
103

K6(C)
XP_045954
KIAA0265
442
7q32.2


K6(N)
NP_005824
p40 Rab9 effector
372
9q34.21
32

K6(C)
NP_055130
HCLP-1, Kelch domain-containing 2
406
14q21.3
104

K6(?)
NP_751943
Kelch domain-containing 1
406
14q21.3


Key. + Splice variants reported. $ No EST match. @spQ96PQ7 encodes a longer protein of 755 amino acids. ^Human LZTR-1 sequence lacks amino-terminus included in mouse NP_080084. (a), human sequence not full-length, mouse orthologue (BAB28596, >90% identity, 574aa) contains a BTB domain (b), human sequence not full-length, mouse orthologue (NP_079983, >90% identity, 571aa) contains a BTB domain. *Kelch-repeat proteins not listed in either Pfam or SMART species trees. Additional domains listed include C-type lectin (CL); C1r, C1s, uEGF, and bone morphogenetic protein domain (CUB or CB); delta serrate ligand (DSL); epidermal growth factor (EGF); fibronectin type III repeats (FNIII); HCF repeats (HCF).

Prag and Adams BMC Bioinformatics 2003 4:42   doi:10.1186/1471-2105-4-42